Objective
Melanoma is the deadliest of the skin cancers. Immune checkpoint inhibitors (ICI), which are blocking antibodies that help to restore antitumor immunity, are currently used for the treatment of metastatic melanoma. However, only approximately 20% of the patients respond to ICI. Understanding the molecular mechanisms behind the resistance to these therapies is essential to predict patients' response and increase treatment success. Extracellular vesicles(EVs), nanosized structures released by virtually all cells, are key mediators of cell-cell communication and horizontal transfer of biomolecules locally and systemically. EVs are known to play an important role in cancer biology by regulating cell apoptosis, angiogenesis, antigen presentation and immune modulation. In recent years, EVs have been shown to also act as protein-decoys, through binding and sequestering soluble proteins, thus preventing protein-target interactions. Previous work from the host group shows that EVs excreted by melanoma cell lines express interferon-γ receptor (IFNGR). Thus, we hypothesize that melanoma-derived EVs modulate the bioavailability and activity of this cytokine. Preliminary results show that EVs isolated from mouse metastatic melanoma B16-F10 cells express IFNGR, bind to IFNγ, and protect tumor cells from the cytotoxic effect of IFNγ. Because resistance to antitumor immunity and to ICI has been linked to defects in IFNγ signaling, this project aims to investigate whether IFNGR+ EVs downregulate IFNγ signaling and ICI response. This research has the potential to unveil a novel yet overlooked cancer immune evasion mechanism mediated by IFNGR+ EVs, which may provide crucial insights to optimize current cancer therapies and ultimately improve patient outcomes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology skin cancer melanoma
- natural sciences biological sciences biochemistry biomolecules proteins
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1400-038 LISBOA
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.