Objective
Cardiovascular diseases (CDs) are the main cause of death in the European Union (EU) and they cost the EU €210 billion a year. Expanding the molecular knowledge on CDs is a key factor in the struggle against them. The sarcoplasmic reticulum (SR) is one of the chief organelles involved in proper cardiomyocyte function due to its implication in calcium handling, and because of that, one of the principal therapeutic targets. SR comprises at least two different regions whose function is well known, however the molecular actors that profile it and how the correct arrangement of them is obtained remain unknown. In contrast, endoplasmic reticulum (ER) shaping and how changes in its shape affects ER function have been recently described. Due to this shape/function relationship and considering the similarities between ER and SR, it is likely that SR shape modulators are fundamental also in maintaining proper SR function. In this scenario, it is tempting to speculate that ER shape alteration is involved in the development of CDs. The aim of this project is to study how the SR shape affects its function. This ambitious goal will be achieved by bringing together my expertise in cardiac physiology with the know-how of my supervisor in ER shape/function and my co-supervisor knowledge on calcium signalling, by using the powerful genetic model Drosophila melanogaster. The results of the project will impact the cardiac function knowledge and could provide possible new therapeutic targets against CDs. Moreover, the results of the project could impact other fields of research, as well as muscular research, by expanding the understanding of SR shape/function relationship.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- medical and health sciences basic medicine physiology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
00185 Roma
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.