Project description
Novel biomimetic bone scaffolds
Bone regeneration is the natural process by which the body repairs and replaces damaged or injured bone tissue and is implicated in fracture healing and overall skeletal health maintenance. It is a complex biological process that involves the recruitment of various cells and the deposition of new bone matrix. In cases of significant bone loss or non-healing fractures, surgeons may use bone grafts or synthetic bone substitutes to facilitate bone regeneration. Funded by the Marie Skłodowska-Curie Actions programme, the AMMagScaff project proposes to develop magnesium alloys as porous scaffolds for bone regeneration. The incorporation of zinc and calcium as well as biodegradable polymers is expected to enhance the mechanical and degradation properties, ultimately eliminating the need for repeat surgeries.
Objective
Porous scaffolds (i.e. lattice implants) play an important role in bone regeneration since they can mimic the structure of bone, bond to bone and in some cases stimulate bone growth. To date, most clinically approved porous scaffolds are limited to those fabricated from non-degradable metals. As such, a second surgery is often required to remove them once their purpose is fulfilled. This is often a burden for the patient and results in significantly increased health care costs. Biodegradable Mg alloys can overcome these issues thanks to their ability to dissolve within the human body while being replaced by new bone tissue. The aim of this project is to advance the potential use of Mg alloy porous scaffolds for bone grafting applications. To achieve this aim, the proposed research seeks to fulfil three primary objectives: (1) to design a next generation biomedical Mg-Zn-Ca alloy suitable for laser-powder bed fusion processing (L-PBF) of porous scaffolds; (2) to improve the mechanical and degradation properties beyond those of ‘benchmark’ commercially available biomedical Mg alloys; (3) to incorporate biodegradable polymers into porous Mg-Zn-Ca-based lattices as a means of improving the functionality of the lattice implant. The project seeks to combine the in-depth material knowledge and industrial experience of the Experienced Researcher (ER), with the biomedical expertise, wide subject background and extensive collaboration networks of the supervisor, Cecilia Persson, along with the broad range of infrastructure available at the host organisation, Uppsala University. The interdisciplinary aspect of the proposed research will enable the ER to expand his knowledge in several areas and will substantially improve his career prospects, especially given the supervisor’s excellent track record of training postgraduate and post-doctoral researchers. The host will benefit from the ER’s contributions to its research activities and industrial relevance.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- medical and health sciencesclinical medicinesurgery
- natural scienceschemical sciencesinorganic chemistryalkaline earth metals
- natural scienceschemical sciencespolymer sciences
- medical and health sciencesmedical biotechnologyimplants
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Keywords
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinator
751 05 Uppsala
Sweden