Objectif
Our goal is to develop all-DNA structures (protocells) that can act as modulators of the immune system and, in particular, of signaling processes in oncology. Molecular DNA switches that interact with cells via aptamers have been developed and used for drug delivery, cell imaging, and potential therapies. However, there are several advantages of incorporating these swithces into protocells, such as the protection of these circuits against degradation, the ability to create gradients and as a delviery method for in vivo application. DNA protocells that (i) have the ability to recognize proteins and small molecules and (ii) amplify signals and generate output that alters cell physiology have not yet been developed. Realizing these structures requires filling a gap in our knowledge of how of how aptamer reactions network in confinement. We anticipate that by filling these gaps in our knowledge, we will be able to produce a pure DNA protocell that can harbor aptamer-based response networks for modulation of intercelullar communication in the tumor microenvironment.
Champ scientifique (EuroSciVoc)
CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN.
CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN.
- sciences naturellessciences biologiquesgénétiqueADN
- sciences naturellessciences biologiquesbiochimiebiomoléculeprotéines
- sciences médicales et de la santémédecine cliniqueoncologie
- sciences médicales et de la santémédecine fondamentalephysiologie
Vous devez vous identifier ou vous inscrire pour utiliser cette fonction
Mots‑clés
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régime de financement
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinateur
55122 Mainz
Allemagne