PRECISION MEDICINE PLATFORM IN NEURODEGENERATIVE DISEASE

Project Information

PROMINENT

Grant agreement ID: 101112145

DOI

10.3030/101112145

EC signature date 25 April 2023

Start date 1 May 2023

End date 30 April 2028

Funded under

• Health

Total cost

€ 11 069 750,00

EU contribution

€ 6 069 750,00

Coordinated by

KAROLINSKA INSTITUTET
Sweden

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (16)

Comms strategy

Communication and dissemination strategy.

HTA consultations

Report on interactions with HTA bodies and recommendations for RWE module.

SLR report

Report from systematic literature review.

RWE module design

Report on framework and protocols for RWE generation.

Validation Study Initiation Package

Documentation for the validation study (protocol, analysis plan, ethics applications).

Interim implementation report

Interim report on indicators of implementation of the digital platform.

Evaluation Study Midterm report

Midterm recruitment report for the evaluation study.

PCAG terms of reference

Terms of reference document for the patient and caregiver advisory group.

Model development report

Report on development of diagnostic & prognostic models.

Website, newsletter and SoMe

PROMINENT website, newsletter and social media.

Evaluation Study initiation Package

Documentation for the evaluation study (protocol, analysis plan, ethics applications).

Report on stakeholder engagement

The impact of the stakeholder engagement will be measured against the indicators adopted in the stakeholder roadmap.

Patient and care partner reports

Report on development of outputs/visualizations for patients and care partners.

Implementation plan

Detail plan and guidance for system implementation.

Interim comms report

Interim report on communication activities.

Stakeholder roadmap

Report on results of stakeholder mapping and tools for engagement.

Data Management Plan (2)

DMP

The DMP will address the relevant aspects of making the data FAIR – findable, accessible, interoperable and re-usable, including what data the project will generate, whether and how the data will be made accessible for verification and re-use, and how it will be circulated and preserved.

Updated DMP

Updated Data Management Plan.

Publications

Peer reviewed articles (11)

The relationship between cognitive domains and everyday functioning in Alzheimer’s disease.

Author(s): Sophie M. van der Landen, Hanneke F. M. Rhodius-Meester, Merel C. Postema, Roos J. Jutten, Mukrabe E. Tewolde, Camar V. Bohnen, Argonde C. van Harten, Charlotte E. Teunissen, Rudolf W. H. Ponds, Benjamin D. Schalet, Wiesje M. van der Flier, Sietske A. M. Sikkes
Published in: Neuropsychology, Issue 40, 2026, ISSN 1931-1559
Publisher: American Psychological Association (APA)
DOI: 10.1037/NEU0001038

Precision medicine in neurodegeneration: the IHI-PROMINENT project

Author(s): Tate A, Suárez-Calvet M, Ekelund M, Eriksson S, Eriksdotter M, Van Der Flier WM, Georges J, Kivipelto M, Kramberger MG, Lindgren P, López JDG, Lötjönen J, Persson S, Pla S, Solomon A, Thurfjell L, Wimo A, Winblad B, Jönsson L
Published in: Frontiers in Neurology, 2023, ISSN 1664-2295
Publisher: Frontiers Research Foundation
DOI: 10.3389/fneur.2023.1175922

Brain MRI volumetry and atrophy rating scales as predictors of amyloid status and eligibility for anti-amyloid treatment in a real-world memory clinic setting

Author(s): A. Zilioli, A. Rosenberg, R. Mohanty, A. Matton, T. Granberg, G. Hagman, J. Lötjönen, M. Kivipelto, E. Westman
Published in: Journal of Neurology, Issue 272, 2025, ISSN 0340-5354
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S00415-024-12853-9

MRI-based atrophy subtypes in a young memory clinic cohort: associations with clinical and biomarker profiles

Author(s): Alessandro Zilioli, Rosaleena Mohanty, Anna Rosenberg, Anna Matton, Tobias Granberg, Göran Hagman, Marco Spallazzi, Daniel Ferreira, Miia Kivipelto, Eric Westman
Published in: Alzheimer's Research & Therapy, Issue 18, 2026, ISSN 1758-9193
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13195-026-01972-2

Focus groups on digital cognitive assessment in the context of Alzheimer's disease

Author(s): Sophie M van der Landen, Rosanne L van den Berg, Matthijs J Keijzer, Mariska N van Liere, Casper de Boer, Leonie N C Visser, Wiesje M van der Flier, Hanneke F M Rhodius-Meester, Sietske A M Sikkes
Published in: DIGITAL HEALTH, Issue 11, 2025, ISSN 2055-2076
Publisher: SAGE Publications
DOI: 10.1177/20552076251318903

Diagnostic and prognostic multimodal prediction models in Alzheimer's disease: A scoping review

Author(s): Xin Xia, Lukas A Duffner, Christophe Bintener, Angela Bradshaw, Daphné Lamirel, Linus Jönsson
Published in: Journal of Alzheimer’s Disease, 2025, ISSN 1387-2877
Publisher: SAGE Publications
DOI: 10.1177/13872877251351630

Deciphering Perspectives: A European survey on clinical decision support tools for dementia and Alzheimer's disease

Author(s): Ini Umoh, Xin Xia, Bengt Winblad, Sandar Aye, Emil Aho, Hanneke F.M. Rhodius-Meester, Linus Jönsson
Published in: Dementia and Geriatric Cognitive Disorders, 2025, ISSN 1420-8008
Publisher: S. Karger AG
DOI: 10.1159/000544801

Enhancing diagnostic precision in Alzheimer's disease: Impact of comorbidities on blood biomarkers for clinical integration

Author(s): Makrina Daniilidou, Ulf Öhlund‐Wistbacka, Göran Hagman, Anna Rosenberg, Nicholas Ashton, Henrik Zetterberg, Kaj Blennow, Anna Matton, Miia Kivipelto
Published in: Alzheimer's & Dementia, Issue 21, 2026, ISSN 1552-5260
Publisher: Wiley
DOI: 10.1002/ALZ.70931

Preparing for the implementation of anti-amyloid therapies in Europe: Assessing real-world eligibility for lecanemab and donanemab in a Swedish memory clinic

Author(s): Anna Rosenberg, Alina Solomon, Alexandre Bonnard, Makrina Daniilidou, Göran Hagman, Anette Hall, Anna Matton, Ulf Öhlund-Wistbacka, Eric Westman, Miia Kivipelto
Published in: The Journal of Prevention of Alzheimer's Disease, Issue 13, 2026, ISSN 2274-5807
Publisher: Elsevier BV
DOI: 10.1016/J.TJPAD.2025.100476

PLoS ONE

Author(s): Rhodius-Meester, H. F. M., van Maurik, I. S., Collij, L. E., van Gils, A. M., Koikkalainen, J., Tolonen, A., Pijnenburg, Y. A. L., Berkhof, J., Barkhof, F., van de Giessen, E., Lötjönen, J., & van der Flier, W. M.
Published in: PloS one, 2024, ISSN 1932-6203
Publisher: PloS
DOI: 10.1371/journal.pone.0303111

Computerized decision support to optimally funnel patients through the diagnostic pathway for dementia

Author(s): Aniek M. van Gils, Antti Tolonen, Argonde C. van Harten, Sinthujah Vigneswaran, Frederik Barkhof, Leonie N. C. Visser, Juha Koikkalainen, Sanna-Kaisa Herukka, Steen Gregers Hasselbalch, Patrizia Mecocci, Anne M. Remes, Hilkka Soininen, Afina W. Lemstra, Charlotte E. Teunissen, Linus Jönsson, Jyrki Lötjönen, Wiesje M. van der Flier, Hanneke F. M. Rhodius-Meester
Published in: Alzheimer's Research & Therapy, Issue 16, 2024, ISSN 1758-9193
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S13195-024-01614-5

Conference proceedings (1)

Differentiating Parkinson‐Plus Syndromes from Other Neurodegenerative Diseases Using Automated T1 MRI Quantification

Author(s): Elena M Bonke, Juha Koikkalainen, Antti Tolonen, Juhana Hakumäki, Patrizia Mecocci, Steen G. Hasselbalch, Hanneke F.M. Rhodius‐ Meester, Bas Jasperse, Afina Willemina Lemstra, Wiesje M. van der Flier, Frederik Barkhof, Jyrki Lötjönen
Published in: Alzheimer's & Dementia, Issue 20, 2025, ISSN 1552-5260
Publisher: Wiley
DOI: 10.1002/ALZ.088632