Project description
A faster, more effective allergy treatment
Allergies are a major global health concern, with respiratory and food allergies affecting 30 % and 10 % of the population, respectively. Many sufferers experience both due to structural similarities between pollen and food allergens. Current treatments focus on symptom relief, which is expensive and inconvenient, while allergen immunotherapy (AIT) remains the only curative option. However, AIT requires years of treatment, has inconsistent efficacy, and is costly for both patients and healthcare systems. The ERC-funded AIDA project aims to revolutionise AIT by developing a therapy that treats multiple allergies simultaneously, accelerates immune tolerance, and minimises side effects. This approach could improve patient outcomes and make allergy treatment more effective and accessible.
Objective
Allergy is a severe immune reaction to foreign substances known as allergens, with respiratory and food allergies affecting 30% and 10% of the global population, respectively. A high structural similarity exists between pollen and food allergens. Therefore, many people suffer from both types of allergies. Untreated allergies have detrimental effects on health-related quality of life, family economics, and work attendance. Allergy is treated as a chronic disease, with a focus on reducing symptoms (e.g. antihistamines), which is cumbersome and expensive. The only existing curative treatment, allergen immunotherapy (AIT), consists of up to 5 years of monthly exposure to low amounts of the triggering allergen until the immune system is desensitized. Unfortunately, this approach is costly for healthcare providers and its efficacy varies, being especially low for patients allergic to multiple pollen and foodstuff sources. Only 40% of patients choose to undergo AIT, and 20% of these terminate the treatment early due to strong side effects or lack of efficacy. We propose the development of an urgently needed AIT by treating several allergies at once, achieving tolerance faster, and reducing side effects.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology other engineering and technologies food technology
- medical and health sciences clinical medicine allergology food allergy
- medical and health sciences basic medicine immunology immunotherapy
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2022-POC2
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2800 Kongens Lyngby
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.