Project description DEENESFRITPL A new era in micro-level disease combat In the intricate realm of healthcare, the challenge of combatting chemoresistant neoplastic lesions under 1 mm in size has persistently confounded medical experts. By evading conventional diagnostic and therapeutic methods, these lesions pose a serious threat to patient well-being. In this context, the EIC-funded PHIRE project aims to reshape this landscape, offering a beacon of hope in the form of a revolutionary high-resolution theranostic medical device that integrates an add-on module for deep organ imaging, guided by AI-driven gold nanorod therapy. Crucially, urine-stable nanorods ensure safety. Overall, PHIRE’s potential to reduce relapses and patient burden marks a paradigm shift. Beyond medicine, PHIRE resonates in imaging, nanotechnology and software markets. Show the project objective Hide the project objective Objective "Health programs crave for diagnostic imaging and eradication of chemoresistant neoplastic lesions smaller than 1 mm of size. PHIRE, based on the outcomes from EDIT (FET-OPEN-RIA, GA#801126), aims at bringing closer to market a novel high-resolution theranostic medical device effective in the clinical applications for lesions <1 mm, ready for application in human bladder cancer and effective both in male and female patients.The PHIRE solution will be developed using swine model and will include:- an add-on module for pre-existing off-the shelf photoacoustic device allowing to perform photoacoustic imaging of hollow organs located deeper in human body, designed to be used in combination with - an artificial intelligence-assisted prediction map for the image-guided gold nanorods assisted photo-thermal therapy,- a large-scale synthesis of urine-stable gold nanorods for clinical use. The adoption for clinical applications of this new device will reduce the frequency of the bladder tumor relapse and the number of patients with relapsing tumor, with a drastic positive impact on the quality of life of patients while reducing the social cost of the management of patients. Furthermore, PHIRE’s results will open up the way for the deployment of theranostic application against lesions <1 mm in other hollow human organs.PHIRE innovative solutions will also be applicable to other markets, such as that of photoacoustic and diagnostic imaging, gold nanoparticles, cystoscopy and medical software." Fields of science natural sciencescomputer and information sciencessoftwaremedical and health sciencesclinical medicineoncologybladder cancerengineering and technologynanotechnologynano-materialsengineering and technologymedical engineeringdiagnostic imaging Keywords High-resolution theranostic approach artificial intelligence cystoscope gold nanorods good manufacturing practices photothermal therapy bladder cancer Programme(s) HORIZON.3.1 - The European Innovation Council (EIC) Main Programme Topic(s) HORIZON-EIC-2022-TRANSITIONOPEN-01 - EIC Transition Open 2022 Call for proposal HORIZON-EIC-2022-TRANSITION-01 See other projects for this call Funding Scheme HORIZON-EIC - HORIZON EIC Grants Coordinator OSPEDALE SAN RAFFAELE SRL Net EU contribution € 701 250,00 Address VIA OLGETTINA 60 20132 Milano Italy See on map Region Nord-Ovest Lombardia Milano Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 701 250,00 Participants (3) Sort alphabetically Sort by Net EU contribution Expand all Collapse all ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA Italy Net EU contribution € 501 121,25 Address VIA ZAMBONI 33 40126 Bologna See on map Region Nord-Est Emilia-Romagna Bologna Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 501 121,88 FUJIFILM SONOSITE BV Netherlands Net EU contribution € 660 000,00 Address JOOP GEESINKWEG 140 1114 AB Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 660 000,00 META Belgium Net EU contribution € 222 500,00 Address AVENUE DES ARTS 6 1210 Sint-Joost-Ten-Node See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 222 500,00 Partners (1) Sort alphabetically Sort by Net EU contribution Expand all Collapse all ASCEND TECHNOLOGIES LIMITED United Kingdom Net EU contribution € 0,00 Address 15-17 CUMBERLAND PLACE SO15 2BG SOUTHAMPTON See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region South East (England) Hampshire and Isle of Wight Southampton Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data
