Objective
The pulmonary tract is an attractive route for direct treatments of lung diseases. Yet, our ability to confine the deposition of inhalation aerosols to specific lung regions, and notably local airways, remains still widely beyond reach with common inhalation therapy. It has been hypothesized that by coupling magnetic particles to inhaled therapeutics the ability to locally target airway sites can be substantially improved. Yet, virtually all practical implementations to date have come short of delivering efficient localized airway targeting. Here, we demonstrate an engineered inhalation framework to leverage magnetically-loaded aerosols for airway targeting in the presence of a custom-designed external magnetic field. By coupling the delivery of a short pulsed bolus of sub-micron (~500 nm diameter) droplet aerosols, laden with super-paramagnetic iron oxide nanoparticles (SPION), with a custom ventilation machine that tracks the volume of air inhaled past the bolus, focused targeting can be maximized during a breath-hold manoeuvre. Our aerosol inhalation platform allows for the first time to deposit inhaled particles to specific airway sites while minimizing superfluous deposition across the respiratory track. This represents a dramatic effort to augment the targeting efficiency (i.e. deposition ratio between targeted and untargeted aerosols). Our first application of focus is aimed at lung cancer. We aim to achieve point targeted delivery of chemotherapeutics directly to lung tumours and lesions through inhalation, thus increasing effective doses and dramatically reducing side effects, in particular relative to detrimental systemic toxicity. AEROTARG embodies a significant paradigm shift in drug delivery modalities aimed for lung cancer therapy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine oncology
- engineering and technology nanotechnology nano-materials
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2022-POC2
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
32000 Haifa
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.