Project description
A step up for cell therapy manufacturing
There is a shortage of personalised cell therapeutics, such as CAR-T therapies. Globally, production levels only reach thousands of doses annually, hindering accessibility for patients in need. In response, an Austrian deep-tech company embarked on a project to scale up manufacturing capacity to hundreds of thousands of doses, cost-effectively and safely. The EU-funded Sarcura project will leverage automation, integration, miniaturisation, and modularity. Its innovative machine platform integrates advanced semiconductor technologies and microfluidic liquid processing systems. By providing comprehensive monitoring of cell count, viability, phenotype characterisation, it aims to achieve a 100-fold increase in cell therapy production. Overall, the project envisions an autonomous, AI-driven manufacturing system.
Objective
Sarcura GmbH, an Austrian deep-tech company founded in November 2019, will develop and market a machine platform for the industrial GMP manufacturing of personalised cell therapeutics, such as CAR-T therapies.
We will contribute to scale the global cell therapy manufacturing capacity of these lifesaving treatments from currently thousands of doses per year to hundreds of thousands of doses, cost effective and safe for all patients. Sarcura envisions to transform existing manufacturing paradigms by using leading-edge semiconductor technologies (such as integrated photonics) embedded in microfluidic liquid processing systems to bring bioprocess control to cellular level.
We believe that only by bringing together automation, integration (of additional functionality), miniaturization, and modularity we can achieve the required 100-fold increase in manufacturing capacity the cell therapy industry requires
Our initial focus is the development of a GMP ready, fully automated, industrial cell isolation device for the manufacturing of cell therapies. The device will include all necessary processing steps to handle the typical starting material of clinical cell therapy as well as provide integrated process analytics and quality control such as cell count, viability, phenotype characterization and other analytics
After launching the first single unit operation device for the Cell Isolation, further devices performing the Formulation, Gene Transfer and Expansion followed by an integrated end-to-end device will be developed. Finally, we aim to market an autonomous, self-optimising manufacturing system based on real-time manufacturing optimisation via AI driven (artificial intelligence) predictive process control.
Our product offer will include (a) desktop instruments, (b) single-use microfluidic cartridges, and (c) software and algorithms.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences artificial intelligence
- medical and health sciences medical biotechnology genetic engineering gene therapy
- social sciences sociology industrial relations automation
- natural sciences physical sciences electromagnetism and electronics semiconductivity
- medical and health sciences medical biotechnology cells technologies
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.2 - European innovation ecosystems
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIE-2022-SCALEUP-02
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3400 KLOSTERNEUBURG
Austria
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.