Description du projet
Faire la lumière sur la dynamique cérébrale liée à l’odorat
Le cerveau traite les informations par le biais de réseaux neuronaux complexes, s’adapte grâce à des mécanismes d’apprentissage et de mémorisation, et intègre les nouvelles connaissances aux cadres existants. L’interaction de diverses régions et processus cérébraux nous permet de percevoir, de comprendre et de naviguer dans le monde qui nous entoure. Financé par le Conseil européen de la recherche, le projet olfACTION s’intéresse aux zones sensorielles du cerveau responsables du traitement des informations provenant de l’olfaction, le sens de l’odorat. Son objectif est de comprendre si les changements induits par l’apprentissage dans les zones sensorielles se produisent indépendamment ou s’ils sont induits par des signaux provenant de zones cérébrales supérieures associées à l’apprentissage et à la mémoire. Les chercheurs étudieront l’activité neuronale et la diffusion de l’information au moyen d’enregistrements électrophysiologiques, de manipulations optogénétiques et d’évaluations anatomiques.
Objectif
Sensory information is initially processed in specialized brain areas but only integration with previously acquired knowledge provides meaningful information for flexible action selection. This requires the propagation of information from sensory to association areas, where sensory information is put into context and memories are acquired. The entorhinal-hippocampal network is of particular importance for information integration and memory formation. Recent findings about learning-induced changes in sensory areas raise the question whether they occur independently or reflect altered top-down influence of the abundant feedback projections from associative areas.
While learning- and context-related changes of activity have been described for individual brain areas, it is largely unknown how learning affects propagation of information between areas. The proposed project aims to dissect the mechanisms by which learning and context shape propagation of sensory information from the olfactory system to the entorhinal-hippocampal network in mice. Olfaction provides unique features to address this aim: a short pathway from sensory to association areas, a discrete time frame for information sampling by respiration, and the capability of mice to quickly learn odor-guided tasks.
The main hypothesis of this project is that timing and synchrony of neuronal activity are key parameters in determining the propagation of information between brain areas and that they are affected by learning and context through feedback projections from association areas. This hypothesis will be tested by simultaneous electrophysiological recordings in olfactory bulb, piriform cortex, lateral entorhinal cortex, and hippocampus during learning of odor-reward associations, combined with optogenetic manipulations and anatomical assessment of connectivity between these areas.
This project will reveal the mechanisms by which learning- and context change the propagation of information between brain areas.
Champ scientifique
Mots‑clés
Programme(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Thème(s)
Régime de financement
HORIZON-ERC - HORIZON ERC GrantsInstitution d’accueil
20251 Hamburg
Allemagne