Unobtrusive Continuous Multi-Metabolite Monitoring for a Physiological Care of Insulin-treated Diabetes

Información del proyecto

MuSiC4Diabetes

Identificador del acuerdo de subvención: 101115233

DOI

10.3030/101115233

Fecha de la firma de la CE 21 Junio 2023

Fecha de inicio 1 Octubre 2023

Fecha de finalización 31 Marzo 2028

Financiado con arreglo a

• The European Innovation Council (EIC)

Coste total

€ 3 885 462,50

Aportación de la UE

€ 3 885 462,50

Coordinado por

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany

Periodic Reporting for period 1 - MuSiC4Diabetes (Unobtrusive Continuous Multi-Metabolite Monitoring for a Physiological Care of Insulin-treated Diabetes)

Período documentado: 2023-10-01 hasta 2024-09-30

Resumen del contexto y de los objetivos generales del proyecto

Diabetes patients carry an enormous burden every day. MuSiC4Diabetes will provide a radically new approach for long-term continuous monitoring of insulin-treated persons with diabetes (ITD) moving from a glucose-only to a Multi-Metabolite (MM) monitoring - glucose, lactate and 3 β OH-butyrate (3-ßOHB) paradigm. MM monitoring will also lead to a diabetes therapy breakthrough by algorithmically driving a continuous physiologic insulin delivery by a maintenance-free implanted MEMS pump using the peritoneal route enabling an optimal therapy for subjects with ITD.

In the first year of project activity, an efficient management structure was established and a number of deliverables were created and submitted to the EC. Work on the tasks according to the work plan began; the project is currently on schedule in all work packages.

As part of the portfolio activities, work began on developing a roadmap and strategy for a healthcare continuum together with researchers from the other projects in this call. M4D contributes to the following groups (Knowledge Exchange (PV), Ethics and Regulation (CHUM), IP and Commercialization (EURICE)). Furthermore, M4D coordinates the Technology Transfer (FHG) group. Those roadmaps will be incorporated into a joint strategy paper in autumn 2024.

Trabajo realizado desde el comienzo del proyecto hasta el final del período abarcado por el informe y los principales resultados hasta la fecha

After establishing efficient management structures, the system was designed and specified with the help of the medical partners. These specifications formed the basis of the design and simulation phase, both for the sensor and for the insulin dosing system. An intensive design and simulation phase followed for key components of the system (MEMS micropump, safety valve), which culminated in the start of a clean room run. Regarding the human factor, a survey of various patient groups was carried out and evaluated with regard to the acceptance of an implantable system. Communication and dissimination activities started (e.g. Webpage https://music4diabetes.eu/ LinkedIn).

Avances que van más allá del estado de la técnica e impacto potencial esperado (incluida la repercusión socioeconómica y las implicaciones sociales más amplias del proyecto hasta la fecha)

Our vision is to completely relieve patients of this daily burden with an implantable system: an implantable multi-parameter sensor measures not only the blood sugar level, but also other parameters such as lactate and ketones, which enables much more precise control. An implantable micropump is designed to deliver a highly concentrated insulin in the abdominal cavity, which is an additional advantage over subcutaneous administration. The patient will not notice any of this, the insulin will only be refilled via a port every three months.

MuSiC4Diabetes Project Logo

Relief for diabetes patients through Music4 Diabetes