Objective
Our intestinal microbiota consists of a dense community of microorganisms, highly adapted to the human gastrointestinal tract. Shared species between individuals indicates the presence of evolved and efficient transmission routes that ensure colonisation of beneficial bacterial species. Research has traditionally focussed on blocking enteric pathogen transmission routes as a means to prevent disease. However, a greater focus on understanding the transmission routes of commensal gut bacteria is required to promote health. Spores are resilient structures that maintain bacterial integrity in a dormant state for extended periods. My previous work has shown that spore-formation is a prevalent phenotype in the intestinal microbiota that promotes transmission of anaerobic gut bacteria, by maintaining viability in adverse aerobic environmental conditions until ingested by a new host. However, despite its importance, sporulation processes in commensal gut bacteria remain poorly understood.
SYNergize will characterise the metabolic capabilities of gut spore-formers, spore composition and the environmental cues involved in spore formation and germination. By identifying combinations of bacteria and nutrients that inhibit enteric pathogens, SYNergize also seeks to provide new approaches to target the problem of increasing antimicrobial resistance in European healthcare systems. These probiotic isolate and prebiotic nutrient combinations can be used to create ‘synbiotics’, rationally designed and ingested to decolonise gut pathogens. A deeper understanding of sporulation processes could also allow spores to be used to effectively deliver anaerobic probiotic bacteria to the gut. By exploring transmission and colonisation processes of intestinal spore-forming bacteria, SYNergize seeks to understand fundamental adaptations of our intestinal microbiota, which could provide new tools to target antibiotic resistant pathogens.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
T12 YN60 Cork
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.