Cel
Our intestinal microbiota consists of a dense community of microorganisms, highly adapted to the human gastrointestinal tract. Shared species between individuals indicates the presence of evolved and efficient transmission routes that ensure colonisation of beneficial bacterial species. Research has traditionally focussed on blocking enteric pathogen transmission routes as a means to prevent disease. However, a greater focus on understanding the transmission routes of commensal gut bacteria is required to promote health. Spores are resilient structures that maintain bacterial integrity in a dormant state for extended periods. My previous work has shown that spore-formation is a prevalent phenotype in the intestinal microbiota that promotes transmission of anaerobic gut bacteria, by maintaining viability in adverse aerobic environmental conditions until ingested by a new host. However, despite its importance, sporulation processes in commensal gut bacteria remain poorly understood.
SYNergize will characterise the metabolic capabilities of gut spore-formers, spore composition and the environmental cues involved in spore formation and germination. By identifying combinations of bacteria and nutrients that inhibit enteric pathogens, SYNergize also seeks to provide new approaches to target the problem of increasing antimicrobial resistance in European healthcare systems. These probiotic isolate and prebiotic nutrient combinations can be used to create ‘synbiotics’, rationally designed and ingested to decolonise gut pathogens. A deeper understanding of sporulation processes could also allow spores to be used to effectively deliver anaerobic probiotic bacteria to the gut. By exploring transmission and colonisation processes of intestinal spore-forming bacteria, SYNergize seeks to understand fundamental adaptations of our intestinal microbiota, which could provide new tools to target antibiotic resistant pathogens.
Dziedzina nauki (EuroSciVoc)
Klasyfikacja projektów w serwisie CORDIS opiera się na wielojęzycznej taksonomii EuroSciVoc, obejmującej wszystkie dziedziny nauki, w oparciu o półautomatyczny proces bazujący na technikach przetwarzania języka naturalnego.
Klasyfikacja projektów w serwisie CORDIS opiera się na wielojęzycznej taksonomii EuroSciVoc, obejmującej wszystkie dziedziny nauki, w oparciu o półautomatyczny proces bazujący na technikach przetwarzania języka naturalnego.
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Słowa kluczowe
Program(-y)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Temat(-y)
System finansowania
HORIZON-ERC - HORIZON ERC GrantsInstytucja przyjmująca
T12 YN60 Cork
Irlandia