Unfolding the dynamic interplay of mechanical and molecular processes in brain folding

Project Information

UNFOLD

Grant agreement ID: 101118729

DOI

10.3030/101118729

EC signature date 19 March 2024

Start date 1 April 2024

End date 31 March 2030

Funded under

• European Research Council (ERC)

Total cost

€ 10 770 990,00

EU contribution

€ 10 770 990,00

Coordinated by

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (1)

Data Management Plan

Publications

Peer reviewed articles (14)

Gene regulatory landscape of cerebral cortex folding

Author(s): Aditi Singh; Lucia Del-Valle-Anton; Camino de Juan Romero;, Ziyi Zhang; Eduardo Fernández Ortuño; Arun Mahesh; Alexandre Espinós; Rafael Soler; Adrián Cárdenas; Virginia Fernández; Ryan Lusby; Vijay K Tiwari; Víctor Borrell
Published in: Science Advances, Issue 10(23), 2024, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adn1640

Biphasic inflammation control by fibroblasts enables spinal cord regeneration in zebrafish

Author(s): Nora John, Thomas Fleming, Julia Kolb, Olga Lyraki, Sebastián Vásquez-Sepúlveda, Asha Parmar, Kyoohyun Kim, Maria Tarczewska, Pooja Gupta, Kanwarpal Singh, Federico Marini, Sumeet Pal Singh, Vasiliki Tsata, Sven Falk, Kristian Franze, Jochen Guck, Daniel Wehner
Published in: Cell Reports, Issue 44, 2025, ISSN 2211-1247
Publisher: Elsevier BV
DOI: 10.1016/J.CELREP.2025.116469

Mechanical positional information guides the self-organized development of a polygonal network of creases in the skin of mammalian noses

Author(s): Paule Dagenais, Ebrahim Jahanbakhsh, Aurélien Capitan, Hélène Jammes, Karine Reynaud, Camino De Juan Romero, Victor Borrell, Michel.C. Milinkovitch
Published in: Current Biology, Issue 34(22), 2024, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2024.09.055

Substrate stiffness and pressure alter retinal Müller glia response and extracellular matrix production

Author(s): Laura Prieto-López, Xandra Pereiro, Emilio J. González Ramírez, Noelia Ruzafa, Alicia Alonso, Kristian Franze, Elena Vecino
Published in: Biomaterials and Biosystems, Issue 19, 2025, ISSN 2666-5344
Publisher: Elsevier BV
DOI: 10.1016/J.BBIOSY.2025.100114

Differential tissue deformability underlies fluid pressure-driven shape divergence of the avian embryonic brain and spinal cord

Author(s): Susannah B.P. McLaren, Shi-Lei Xue, Siyuan Ding, Alexander K. Winkel, Oscar Baldwin, Shreya Dwarakacherla, Kristian Franze, Edouard Hannezo, Fengzhu Xiong
Published in: Developmental Cell, Issue 60, 2025, ISSN 1534-5807
Publisher: Elsevier BV
DOI: 10.1016/J.DEVCEL.2025.04.010

Stripe out for brain evolution: Astrocytes go human

Author(s): Lara López-González, Víctor Borrell
Published in: Cell Stem Cell, Issue 32, 2025, ISSN 1934-5909
Publisher: Elsevier BV
DOI: 10.1016/J.STEM.2025.02.008

Microdissection and Single-Cell Suspension of Neocortical Layers From Ferret Brain for Single-Cell Assays

Author(s): Valle-Anton, Lucia del; Amin, Salma; Borrell, Víctor
Published in: BIO-PROTOCOL, Issue 14(24), 2024, ISSN 2331-8325
Publisher: Bio Protoc
DOI: 10.21769/BIOPROTOC.5133

Mouse cortical organoids reveal key functions of p73 isoforms: TAp73 governs the establishment of the archetypical ventricular-like zones while DNp73 is central in the regulation of neural cell fate

Author(s): Alonso Olivares, Hugo; Marqués Martínez, Margarita; Prieto Colomina, Anna; López Ferreras, Lorena; Martínez García, Nicole; Vázquez Jiménez, Alberto; Borrell Franco, Víctor; Marín Vieira, María Carmen; Fernández Alonso, Rosalía
Published in: Frontiers in Cell and Developmental Biology, 2024, ISSN 2574-1241
Publisher: Frontiers in Cell and Developmental Biology
DOI: 10.3389/FCELL.2024.1464932

Measurement force, speed, and postmortem time affect the ratio of CNS gray-to-white-matter elasticity

Author(s): Julia Monika Becker, Alexander Kevin Winkel, Eva Kreysing, Kristian Franze
Published in: Biophysical Journal, 2025, ISSN 0006-3495
Publisher: Elsevier BV
DOI: 10.1016/J.BPJ.2025.03.009

Environmental stiffness regulates neuronal maturation via Piezo1-mediated transthyretin activity

Author(s): Eva Kreysing, Hélène O. B. Gautier, Sudipta Mukherjee, Katrin A. Mooslehner, Leila Muresan, Daniel Haarhoff, Xiaohui Zhao, Alexander K. Winkel, Tina Borić, Sebastián Vásquez-Sepúlveda, Niklas Gampl, Andrea Dimitracopoulos, Eva K. Pillai, Robert Humphrey, Ragnhildur Thóra Káradóttir, Kristian Franze
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-64810-3

Keep calm and make neurons: The effects of glucocorticoids on human cortical neurogenesis

Author(s): Virginia Fernández; Víctor Borrell
Published in: Neuron, Issue 112(9), 2024, ISSN 0896-6273
Publisher: Neuron
DOI: 10.1016/j.neuron.2024.04.004

Epi-regulate my brain: unlocking mechanisms of brain growth evolution

Author(s): Virginia Fernández; Víctor Borrell
Published in: The EMBO Journal, Issue 43(8), 2024, ISSN 1460-2075
Publisher: Nature Publishing Group UK
DOI: 10.1038/s44318-024-00083-8

Early neuronal inhibition sculpts adult cortical interhemispheric connectivity

Author(s): Míriam Javier-Torrent, Antonela Bonafina, Laurent Nguyen
Published in: Trends in Neurosciences, Issue 47, 2024, ISSN 0166-2236
Publisher: Elsevier BV
DOI: 10.1016/j.tins.2024.08.002

Ccp1 depletion disrupts network integration of hippocampal parvalbumin interneurons

Author(s): Romain Le Bail, Bernard Lakaye, Ira Espuny-Camacho, Carsten Janke, Maria M. Magiera, Dominique Engel, Carla G. Silva, Laurent Nguyen
Published in: iScience, Issue 28, 2025, ISSN 2589-0042
Publisher: Elsevier BV
DOI: 10.1016/J.ISCI.2025.113215