Project description
Training and treatment against oesophageal cancer
Cancer is anticipated to become the leading cause of death in the EU by 2035. Oesophageal cancer, characterised by high resistance and varying responses to treatment, exhibits poor outcomes. The absence of a unified low-risk strategy for this disease contributes to divergent outcomes and cancer inequalities in Europe. The EU-funded PRESSURE project seeks to address this challenge by training 10 experts to develop effective treatments and policies against therapy resistance in cancer. With a specific focus on oesophageal adenocarcinoma – one of the most complex cancer types requiring innovative solutions – the project aligns with Horizon Europe's Plan to Beat Cancer. Through extensive intersectoral training, PRESSURE aims to equip researchers with comprehensive knowledge spanning the entire cancer treatment value chain.
Objective
In 2035, cancer will have become the leading cause of death in the EU. In line with the Horizon Europe Plan to Beat Cancer, one of the five Horizon Missions, the PRESSURE network sets out to train 10 future experts who will push the development and clinical implementation of effective treatments and policies against therapy resistance in cancer. This innovative project will specifically focus on esophageal adenocarcinoma as one of the most complex cancer types in terms of resistance, and most urgently in need of novel solutions.
Prominent factors that contribute to the poor outcome of esophageal cancer are a high degree of acquired resistance, and heterogeneous responses to the available therapies. Despite this knowledge, there are currently no consensus treatments for this disease in the EU, and there is insufficient awareness of the need for a unified low-risk treatment strategy. Numerous different regimens are currently given across the continent, and as a result highly divergent outcomes of EAC are observed. This adds to Cancer Inequalities in Europe.
To address this, PRESSURE researchers will receive exhaustive intersectoral training, and deliver high-quality knowledge, across the entire value chain: Epidemiology, imaging, patient-derived model systems, resistance mechanisms, diagnostics, patient-centricity, valorization, and treatment. By receiving this diverse training, the ESRs will become next generation thinkers and problem-solvers, and will be able to deliver creative contributions to all fields involved in the combatting of cancer with unique solutions applicable in the clinic and society. This combination of complementary research expertise and rich training is not currently offered in an EU network.
Fields of science
Keywords
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral NetworksCoordinator
1081 HV Amsterdam
Netherlands
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Participants (7)
04109 Leipzig
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75654 Paris
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17177 Stockholm
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90133 Palermo
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656 53 Brno
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2730 Herlev
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
16121 Genova
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partners (12)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
3511 LC UTRECHT
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3521 AL Utrecht
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1210 Bruxelles / Brussel
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5038 KE Tilburg
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35000 Slavonski Brod
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3531AH Utrecht
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1012WX Amsterdam
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1081 HV Amsterdam
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34090 Montpellier
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601 77 Brno
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1165 Kobenhavn
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
20126 MILANO
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