Project description
Advancing targeted therapies for aggressive breast cancer
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer that accounts for more than 10 % of cases, often affecting younger patients. Within just 2-3 years, approximately 30 % of those diagnosed develop incurable distant metastases. Despite ongoing research, treatment remains limited to surgery and chemotherapy. One promising avenue involves nitric oxide (NO) signalling, which plays a dual role in tumour progression. Supported by the Marie Skłodowska-Curie Actions programme, the NO-CANCER-NET project harnesses this knowledge to develop therapies by targeting inducible nitric oxide synthase (iNOS). It will train researchers in tumour biology, drug development, and computational analysis, bridging the gap between laboratory research, industry, and clinical application.
Objective
NO-CANCER-NET will focus on Triple Negative Breast Cancer (TNBC) and Nitric Oxide (NO)-related therapeutic development. TNBC accounts for 10-20% breast cancers and is characterised by diagnosis at an early age and an aggressive phenotype. It indeed develops incurable distant metastasis within the first 2-3 years in approximately 30% patients. Despite significant efforts, TNBC treatment is limited to surgery and chemotherapy laying bare the urgent need for new targeted therapeutic development. Our network has demonstrated an important role for inducible nitric oxide synthase (iNOS) and NO signalling in TNBC metastatic progression, with efficacy of iNOS targeting demonstrated in a phase I/II clinical trial of patients with distant metastasis. Based on NO’s yin/yang effect on tumour biology, iNOS/NO system can be targeted by either inhibiting iNOS and reducing the physiological levels of NO which drive tumour progression, or vice versa using NO donating drugs to increase NO to tumouricidal levels (similar to immune cells NO-mediated tumour targeting).
The NO-CANCER-NET Doctoral Network (DN) addresses two fundamental gaps in European training: 1) a network where a core of Doctoral Candidates (DCs) can share a basic understanding of molecular target discovery, models of tumour biology assessment, drug synthesis and delivery, developing diagnostics, handling complex spatial imaging and omics expression data profiles; and 2) solid interdisciplinary training in experimental, computational and clinical research. NO-CANCER-NET will equip our DCs to understand the complexities of bench to bedside cancer research, the importance of an interdisciplinary approach and an understanding of the fundamentals of related disciplines. This will be of great importance in preparing DCs to work between academia, industry and in clinical healthcare providers.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine surgery
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
H91 Galway
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.