Project description
A new way to treat inflammatory bowel disease
Millions of people in Europe suffer from inflammatory bowel disease (IBD), a lifelong condition that causes severe inflammation in the gut. It includes Crohn’s disease and ulcerative colitis, which lead to pain, digestive problems, and serious complications. Over time, chronic inflammation increases the risk of colorectal cancer. Despite many treatment options, there is still no cure, and the economic burden exceeds EUR 5 billion per year. In this context, the ERC-funded FLAMINCO project is developing a new type of treatment for IBD. It will test molecules in advanced disease models, with the goal of creating a therapy that can improve patient outcomes.
Objective
Inflammatory Bowel Disease (IBD) a major cause of colorectal cancer (CRC) and a huge socioeconomic burden in Europe and beyond. IBD comprises diseases that are characterized by chronic inflammation in the gastrointestinal tract and includes ulcerative colitis (UC) and Crohns disease (CD). These diseases are lifelong, causing debilitating symptoms and can be life-threatening. IBD is caused by an interplay between the patients genetic predisposition, immune responses and environmental factors. Chronic inflammation with fibrosis is the key driver of disease complications such as stenosis, abscess formation and colon cancer. IBD affects about 3.2 million people in Europe. IBD patients have an increased risk of CRC caused mainly by chronic intestinal inflammation leading to pro-neoplastic effects. In fact, IBD patients have an alarming 2- to 5- fold increased risk of developing CRC compared to the general population. Despite many treatment options, there is no cure for IBD. The IBD health economic burden in Europe is high and estimated at over 5B /year. It is widely accepted that to overcome the challenges and to break through the therapeutic ceiling combination therapies or completely novel approaches will be needed. Due to the increasing incidence and prevalence and associated burden of IBD, the lack of effective long-term treatment options and the associated risks including CRC; IBD remains an important unmet medical need with an urgent need for novel therapies that can improve patient outcome. Here we will explore the use of a completely novel class of molecules exploiting a unique first-in-class mechanism-of-action and validate their efficacy as a therapeutic for IBD. Proof-of-concept studies will be performed in state-of-the-art mouse models. The data obtained will represent a robust data package towards IND for this indication. We propose a novel therapeutic option for IBD that has the potential to address this important unmet medical need.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-POC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75654 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.