Targeting the undruggable: Leveraging neomorphic DNA-binding preferences of chimeric fusion oncogenes to promote cancer suicide

Project Information

Cancer-Harakiri

Grant agreement ID: 101122595

DOI

10.3030/101122595

EC signature date 8 December 2023

Start date 1 January 2024

End date 31 December 2028

Funded under

• European Research Council (ERC)

Total cost

€ 1 992 235,00

EU contribution

€ 1 992 235,00

Coordinated by

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (9)

Nature Communications

Author(s): Merve Kasan; Florian H. Geyer; Jana Siebenlist; Martin Sill; Rupert Öllinger; Tobias Faehling; Enrique de Álava; Didier Surdez; Uta Dirksen; Ina Oehme; Katia Scotlandi; Olivier Delattre; Martina Müller-Nurasyid; Roland Rad; Konstantin Strauch; Thomas G. P. Grünewald; Florencia Cidre-Aranaz
Published in: Nature Communications, 2025, ISSN 2041-1723
Publisher: Springer Nature
DOI: 10.1038/S41467-024-55340-5

Nature Communications

Author(s): Darui Jin; Shangying Liang; Artem Shmatko; Alexander Arnold; David Horst; Thomas G. P. Grünewald; Moritz Gerstung; Xiangzhi Bai
Published in: Nature Communications, 2023, ISSN 2041-1723
Publisher: Springer Nature
DOI: 10.1101/2023.07.26.550748

Cell Death and Disease

Author(s): Sonja Herter; Marta Emperador; Kyriaki Smyrilli; Daniela Kocher; Simay Celikyürekli; Constantia Zeiser; Xenia Gerloff; Sina Kreth; Kai-Oliver Henrich; Kendra K. Maaß; Johanna Rettenmeier; Thomas G. P. Grünewald; Heike Peterziel; Frank Westermann; Anne Hamacher-Brady; Olaf Witt; Ina Oehme
Published in: Cell Death & Disease, 2025, ISSN 2041-4889
Publisher: Springer Nature
DOI: 10.1038/S41419-025-07933-1

Molecular Cancer

Author(s): Bull, E.C.; Singh, A.; Harden, A.M.; Soanes, K.; Habash, H.; Toracchio, L.; Carrabotta, M.; Schreck, C.; Shah, K.M.; Riestra, P.V.; Chantoiseau, M.; Da Costa, M.E.M.; Moquin-Beaudry, G.; Pantziarka, P.; Essiet, E.A.; Gerrand, C.; Gartland, A.; Bojmar, L.; Fahlgren, A.; Marchais, A.; Papakonstantinou, E.; Tomazou, E.M.; Surdez, D.; Heymann, D.; Cidre-Aranaz, F.; Fromigue, O.; Sexton, D.W.; Herold, N.; Grünewald, T.G.P.; Scotlandi, K.; Nathrath, M.; Green, D.
Published in: Molecular Cancer, 2025, ISSN 1476-4598
Publisher: BioMed Central
DOI: 10.1186/S12943-025-02365-Z

Nature Communications

Author(s): Tal Levy; Kai Voeltzke; Laura Hruby; Khawla Alasad; Zuelal Bas; Marteinn Snaebjörnsson; Ran Marciano; Katerina Scharov; Mélanie Planque; Kim Vriens; Stefan Christen; Cornelius M. Funk; Christina Hassiepen; Alisa Kahler; Beate Heider; Daniel Picard; Jonathan K. M. Lim; Anja Stefanski; Katja Bendrin; Andres Vargas-Toscano; Ulf D. Kahlert; Kai Stühler; Marc Remke; Moshe Elkabets; Thomas G. P. Grünewald; Andreas S. Reichert; Sarah-Maria Fendt; Almut Schulze; Guido Reifenberger; Barak Rotblat; Gabriel Leprivier
Published in: Nature Communications, 2024, ISSN 2041-1723
Publisher: Springer Nature
DOI: 10.1038/S41467-024-48386-Y

Nature Communications

Author(s): Galvan, Bartimée; Ongena, Loïc; Bruyr, Jonathan; Fettweis, Grégory; Lucarelli, Eva; Lavergne, Arnaud; Mariavelle, Emeline; O'Grady, Tina M; Hassoun, Zahrat El Oula; Claes, Margaux; Dubois, Laurence; Lee, Kevin A W; Kruys, Véronique; Gueydan, Cyril; Durand, Jules; Hervouet, Eric; Geyer, Florian H; Banito, Ana; Imle, Roland; Mao, Lianghao; Jayavelu, Ashok K; Grünewald, Thomas G P; Cidre-Aranaz, Florencia; Twizere, Jean-Claude; Dequiedt, Franck
Published in: Nature Communications, 2025, ISSN 2041-1723
Publisher: Springer Nature
DOI: 10.1038/S41467-025-61725-X

Cancers

Author(s): Wachtel, Marco; Surdez, Didier; Grunewald, Thomas G P; Schäfer, Beat W
Published in: Cancers, 2024, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.5167/UZH-269234

High Tau expression correlates with reduced invasion and prolonged survival in Ewing sarcoma

Author(s): Florencia Cidre-Aranaz; Claudia Magrin; Malenka Zimmermann; Jing Li; Anna Lisa Baffa; Matteo Ciccaldo; Wolfgang Hartmann; Uta Dirksen; Martina Sola; Paolo Paganetti; Thomas G P Grünewald; Stéphanie Papin
Published in: Cell Death Discovery, 2025, ISSN 2058-7716
Publisher: Nature Publishing Group (Nature Portfolio / Springer Nature)
DOI: 10.1101/2025.02.10.635652

Nature Communications

Author(s): Willemijn Breunis; Eva Brack; Anna C. Ehlers; Ingrid Bechtold; Samanta Kisele; Jakob Wurth; Lieke Mous; Dorita Zabele; Fabio Steffen; Felina Zahnow; Christian Britschgi; Lorenz Bankel; Christian Rothermundt; Cornelia Vetter; Daniel Müller; Sander Botter; Chantal Pauli; Peter Bode; Beate Rinner; Jean-Pierre Bourquin; Jochen Roessler; Thomas G. P. Grünewald; Beat W. Schäfer; Didier Surdez; Marco Wachtel
Published in: Nature Communications, 2025, ISSN 2041-1723
Publisher: Springer Nature
DOI: 10.48620/90923