Project description
Novel 3D system for drug efficacy assessment
The development of new drugs is long and costly, requiring better systems for early testing. The ERC-funded TissMec project addresses this need by creating 3D human tissue models with an automated, scalable platform to assess drug safety and efficacy. Unlike currently used manual methods, TissMec can measure the mechanical properties of the tissue, such as muscle force generation, viscoelastic properties, and disease-relevant mechanical conditions, in a standardised 96-well format. This innovation allows early identification of problematic compounds and has the potential to accelerate drug development. TissMec is expected to revolutionise pharmacology and toxicology by improving efficiency and reliability in preclinical testing.
Objective
The way from potential drug candidates to clinically approved new medication is long and expensive. To improve this, we will provide the TissMec system that can create 3D human tissue while providing an automated and scalable way to quantify potential problems of drugs and other compounds of interest. Our TissMec system can not only measure the force generation of muscles and other contractile tissue but also continuously determine the viscoelastic tissue properties while mimicking mechanical situations that are known hallmarks of several critical diseases. Up to now, obtaining such information is either not possible or requires slow and expensive manual work. Hence, an automated, scalable and standardized (96 well) system that can quickly screen properties on human tissue can become a game-changer, as it identifies problematic drugs and compounds very early in the drug development process. We have a laboratory prototype (TRL4) that already demonstrates these capacities, and the proposed PoC project will develop this lab version into a user-friendly TRL6 prototype that we can give to our partners in pharmacology and toxicology and to already well-established industry partners. Our team is composed of 5 scientists spanning physics, biology, chemistry, data science, and economy. Hence, we not only have invented a new technology to greatly improve an urgent current problem but also have a powerful network and outstanding team to ensure the success of our project.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- medical and health sciences basic medicine toxicology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-POC
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
37073 Gottingen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.