Project description
3D bioprinting for complex tissues
Replicating the intricate multi-scaled vasculature of human tissues and organs remains a critical hurdle in 3D bioprinting, limiting advancements in tissue engineering and regenerative medicine. Current bio-fabrication techniques struggle to achieve the complexity and functionality required for practical applications. Simplified structures and mechanical limitations hinder the development of biologically accurate tissue-like systems. The ERC-funded HOT-BIOPRINTING project will introduce Holographic Optical Tweezing Bioprinting (HOTB). This innovative, non-contact light-based technology enables high-definition 3D printing of single and multiple cells, overcoming traditional limitations. With HOTB, researchers can fabricate complex, vascularised tissues (like functional lymph nodes), thereby potentially transforming the future of medical treatments and bioengineering.
Objective
Because current limitations in 3D bioprinting for tissue engineering stem from the fact that the multi-scaled vasculature associated to the human microtissues and organs cannot be replicated. The overarching aim of the HOT-BIOPRINTING project is to deliver a methodology enabling the manufacturing of a new generation of tissue-like structures with properties mimicking more closely the complexity of biological tissues and organs. The innovation of HOT-BIOPRINTING lies on the development of a disruptive technology named Holographic optical tweezing bioprinting (HOTB) for single and automatized multiple cell 3D bioprinting. The non-contact nature of light will eliminate the fails on bioprinting associated to instrumentation, which along with the HOTB capabilities for manipulating single cells for printing will drive a new paradigm shift: “resolution will be dictated by the cell size instead of by the mechanical component of the instrumentation”. This new technological advancement for resolution enhancement while maintaining bioprinting speed using holographic automatization can open new opportunities to the tissue engineering and regenerative medicine community.
I propose the following general objectives that go beyond the state of the art in bioprinting human mimetic tissue:
1) Generate the knowledge and develop a Holographic Optical tweezer bioprinter (HOTB) for high-definition single/multiple cell bioprinting.
2) Demonstration and automatization for 3D multicellular printing for large area tissue generation.
3) Overcome the challenges associated with existing biofabrication techniques (limited multi-scaled vascularization and oversimplified structures).
4) Demonstrating lymph-node bioprinting with integrated vasculature.
This represents a big challenge, if achieved, will revolutionize the bioprint technology by increasing the tissue complexity and by responding to the demand of biofabricating multi-scale vascularized complex tissues and organs.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-COG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
15001 La Coruna
Spain
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