Objective
This proposal addresses the combined role of early life derived B cells in the adult immune system. Neonatal immune imprinting is now well-established concept. It emphasizes the importance of the early life window to establish host-microbial mutualism and the set-point for immune responsiveness later in life. However, the cellular and molecular mechanisms underlying this immune programming are not well understood. Despite the ability of B cells to integrate and store complex immunological memory for a lifetime, surprisingly little is known about its ability to confer the longitudinal effects of neonatal microbial instruction.
By time-stamping B cells that arise early in life, my research team resolved a self-sustaining network of IgM and IgA B and plasma cells that carry memory of neonatal exposure. Such early life origin B (ELO-B) cells are unevenly distributed among immunophenotypically and anatomically defined B cell subsets and make up a substantial portion of the adult B cell pool in unimmunized mice. These findings reveal pervasive neonatal antigenic imprinting of the adult B cell compartment, challenging the assumption that the adaptive immune system is nave in the absence of deliberate immunization. With this understanding arises an urgent need to dissect the formation and function of ELO-B cell memory and their lasting impact on host protection and long-term homeostasis. To this end, we have built an unprecedented genetic toolkit leveraging the power of our time-stamping approach, to track and manipulate ELO-B cell responses without perturbing adul
Overarching hypothesis: ELO-B cells uniquely imprinted by developmental and microbial determinants early in life shape the trajectory of adult immune responses in health and disease.
Aim 1. Dissecting the formation of a complex ELO-B cell layer.
Aim 2. Tracing ELO-B cell derived antibodies and their contribution to adult B cell responses.
Aim 3. Defining the role for ELO-B cells in immunological tolerance.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine immunology immunisation
- natural sciences biological sciences biological behavioural sciences ethology biological interactions
- medical and health sciences basic medicine physiology homeostasis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-COG
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22100 Lund
Sweden
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