Objective
The objective of ELIMINATE-CKD is to demonstrate that combining measures of kidney structure and function will strongly enhance detection of chronic kidney disease (CKD). To reach this objective, I will develop a new method to quantify the number of nephrons, the smallest functional units in the kidney.
Rationale:
- CKD affects ~10% of the global population and causes 2.6 million deaths/year. CKD-associated costs (140 billion euros/year in Europe) exceed diabetes and cancer. Limitations in CKD detection impede the success of emerging therapies.
- Current CKD definition is based on creatinine-based estimated glomerular filtration rate, which is often inaccurate due to interindividual differences in body composition and compensation for early kidney damage as remaining nephrons increase their function.
- Using a unique combination of multi-omics and machine learning approaches in human cohorts and innovative animal models, I will dissect pathways that drive nephron number and enable its quantification.
Concrete objectives are to:
1) Develop a high-throughput method to quantify nephron number in large human cohorts and a novel rat model of gradual nephron reduction
2) Construct and validate unbiased and hypothesis-driven nephron number algorithms based on kidney-derived proteins, lipids and metabolites in blood and urine
3) Demonstrate that nephron number algorithms enable earlier and more accurate CKD detection
4) Provide proof of principle that nephron number-triggered therapy prevents or halts CKD
Impact:
This project will lead to a new CKD classification, based on both structure and function. Identification of mechanisms driving nephron number will boost drug development and regenerative medicine towards nephron-preserving therapies. Finally, the concept of structure-function relationship is relevant in many other organs (brain, heart). My passion to beat kidney disease by innovative diagnostics drives me towards my ultimate goal: to eliminate CKD.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine endocrinology diabetes
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-COG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
9713 GZ Groningen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.