Project description
Altered brain-periphery communication: potential predictor of future complications
The peripheral nervous system, consisting of nerves that branch off the spinal cord and innervate peripheral organs, both sends information to and receives information from the central nervous system consisting of the brain and spinal cord. The ERC-funded CrossPeriBrain project observed in earlier studies of diabetes that high-risk phenotypes predicting future life-threatening complications of diabetes, even before diabetes onset, were similar to those of subjects with altered periphery-brain communication. Based on this information, the project will use pioneering experimental research in humans combined with advanced data analyses aiming to investigate a relationship between altered brain-periphery communication and very high-risk phenotypes. This could support interventions for the prevention and treatment of life-threatening complications.
Objective
Diabetes is a leading cause for morbidity and mortality worldwide. In our fight against the diabetes pandemic, my team and I recently identified subgroups of humans that are predictive for future life-threatening complications even before diabetes onset. Classification into these new risk groups is currently purely based on extensive phenotyping, yet, the underlying mechanisms are unclear. Of note, phenotypes of very high-risk persons are highly reminiscent of those from subjects with altered periphery-brain communication.
I will combine ground-breaking experimental research in humans with latest data analysis approaches to delineate the causal relationship between altered brain-periphery communication and very high-risk phenotypes.
The 1st aim will reveal disturbances in the brain-periphery communication in high-risk persons. I will identify differences in the transduction of neuronal signals to the target organs, discover regulators from the brain to the periphery, and elucidate the regulation of underlying pathways.
The 2nd aim will clarify signalling from the periphery to the brain. I will unravel the dynamic interaction between insulin and gut-derived hormones on the brain, identify signalling patterns that inform the brain about food intake and determine disturbances thereof in high-risk persons, and I will non-invasively characterize postprandial molecular responses in neurons.
The 3rd aim develops a novel, non-invasive approach to identify high-risk persons by their altered brain-periphery communication. It will apply the above-generated knowledge to develop an algorithm-based integration of health data.
Ultimately, my project will innovatively define the impact of altered brain-periphery crosstalk in the development of clinically relevant high-risk groups. It will set ground for novel approaches that optimize prevention and treatment of major complications and thereby improve future health, way beyond what is achieved by current approaches.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- medical and health sciences health sciences public health epidemiology pandemics
- medical and health sciences clinical medicine endocrinology diabetes
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-COG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
89081 Ulm
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.