Breaking down barriers to foster new Cyclodextrin-based applications for healthcare by implementing sustainable design principles

Project Information

Bicyclos

Grant agreement ID: 101130235

DOI

10.3030/101130235

EC signature date 28 July 2023

Start date 1 September 2023

End date 31 August 2027

Funded under

• Marie Skłodowska-Curie Actions (MSCA)

Total cost

No data

EU contribution

€ 1 297 200,00

Coordinated by

CONSIGLIO NAZIONALE DELLE RICERCHE
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (1)

Data Management Plan

Data management plan and updates

Websites, patent fillings, videos etc. (1)

Webpage, blog, Infographics

Bicyclos webpage and blog (>M3) and updates; Bicyclos Infographics (>M6)

Other (1)

Dissemination, Exploitation and Communication plan

Dissemination, Exploitation and Communication plan (DEC) plan (M6) and updates (M48) submitted to EC

Documents, reports (1)

International School 1

International School “New approaches to sustainable synthetic chemistry ofcarbohydrates and derivatives” and “Advanced models in substitution of animal studies for drug development” with Schedule, programme and lectures in cloud.

Publications

Conference proceedings (27)

β-Cyclodextrin-Based Geometrically Frustrated Amphiphiles: Synthesis, Self-Assembly and DNA Delivery Capabilities

Author(s): José M. G. Fernandez, G. Rivero-Barbarroja, José López-Fernández, Inmaculada Juárez-Gonzálvez, Carlos Fernández-Clavero, Christophe Di Giorgio, Itziar Vélaz, María J. Garrido, Juan M. Benito, Carmen Ortiz Melet, Francisco Mendicuti, C. Tros de Ilarduya
Published in: The 29th days of the French Group of Glycosciences, 2024
Publisher: IIQ

Cyclodextrin-Azobenzene Hybrids: Photoresponsive Self-Assembly and Co-Assembly with DNA

Author(s): Gonzalo Rivero Barbarroja, Carlos Fernández Clavero, Cristina García-Iriepa, Gema Marcelo, M. Carmen Padilla-Pérez, Tania Neva, Juan M. Benito, Stephane Maisonneuve, Carmen Ortiz Mellet, Joanne Xie, José M. García Fernández, Francisco Mendicuti
Published in: NanoBioMat 2023 - Winter Edition, 2023
Publisher: IIQ

Development and in vitro-in vivo evaluation of active targeted multidrug loaded nanoparticles to overcome drug resistance in the treatment of nonhodgkin lymphoma

Author(s): Demirtürk Nese
Published in: Congressus Pharmaceuticus Hungaricus Xvıı. And Eufeps Annual Meeting 2024, 2024
Publisher: x8

Cyclodextrin Polymers for Scalable Green Photooxygenation of Aromatic Substrates in Water

Author(s): Ilse Manet; Marco Agnes; Arianna Mazza; Eszter Kalydi; Szabolcs Béni; and Milo Malanga
Published in: PhotoIUPAC, 2024
Publisher: IRIS CNR

Multipoint click-chemistry functionalization of cyclodextrins: Precision synthesis of giant bola-amphiphiles exhibiting nucleic acid complexing properties

Author(s): Sergio Adorna-Sánchez, Gonzalo Rivero-Barbarroja, Theo Stahl, José López-Fernández, Inmaculada Juárez-Gonzálvez, Christophe Di Giorgio, Itziar Vélaz, María J. Garrido, Juan M. Benito, Conchita Tros de Ilarduya, Carmen Ortiz Mellet, Jose M. García Fernánd
Published in: 8° Congreso de Estudiantes de Doctorado en Química, 2024
Publisher: IIQ

Light-Responsive DNA Delivery with Cyclodextrin-Based Lipid-Cationic Azobenzene Dendron Host-Guest Vectors

Author(s): Puerto-Madorran MJ, Xie J, Maisonneuve S., Benito JM, Garcia Fernandez JM, Ortiz Mellet C
Published in: 5th Conference on Innovation in Drug Delivery, 2024
Publisher: IIQ

Broadening the Landscape of Cyclodextrin-Based Vectors for Cell-Selective Nucleic Acid Delivery

Author(s): José Lopez-Fernández, Gonzalo Rivero-Barbarroja, Juan M. Benito, Inmaculada Juárez-Gonzálvez, Carlos Fernández-Clavero, Itziar Vélaz, Marìa J. Gamido, Carmen Ortiz Mellet, Francisco Mendicuti, Conchita Tros de Ilarduya, José M. García Fernández
Published in: NanoBioMat 2023 - Winter Edition, 2023
Publisher: IIQ

Collection of Abstracts of contributions presented by Bicyclos partners at 8th EuroCD conference, 2025

Author(s): Marco Agnes, Milo Malanga, Tamas Sohajda, Balazs Attila Kondoros, Mary McNamara, Keivan Sadrerafi, Claudia Felicia Mautone
Published in: 2025
Publisher: Zenodo
DOI: 10.5281/ZENODO.17131577

Unlocking Cell- And Organ-Specific Transfection With Cyclodextrins: Geometrically Frustrated Amphiphiles

Author(s): José Manuel García Fernández, Gonzalo Rivero-Barbarroja, José López-Fernández, Inmaculada Juárez-Gonzálvez, Carlos Fernández-Clavero, Christophe Di Giorgio, Itziar Vélaz, Maria J. Garrido, Juan M. Benito, Conchita Tros de Ilarduya, Francisco Mendicuti and
Published in: The 31st International Carbohydrate Symposium, 2024
Publisher: IIQ

Optimization and Characterization of Rituximab-Targeted Cyclodextrin Nanoparticles for Multidrug Delivery in the Treatment of Non-Hodgkin Lymphoma

Author(s): Varan Gamze, Demirtürk Nese, Kağa Sadik, Malanga Milo, Bilensoy Erem
Published in: 21st International Pharmaceutical Technology Symposium, 2024
Publisher: x9

Cyclodextrin polymers as versatile tools for homogeneous photochemistry in water to produce oxygen releasing agents 

Author(s): Ilse Manet
Published in: EuChemS, 2024
Publisher: Zenodo
DOI: 10.5281/ZENODO.17019883

Cyclodextrin-Based Giant Bola-Amphiphiles: Synthesis, Self-Assembly And Gene Delivery Capabilities

Author(s): Sergio Adorna-Sánchez, Gonzalo Rivero-Barbarroja, Theo Stahl, José López-Fernández, Inmaculada Juárez-Gonzálvez, Christophe Di Giorgio, Itziar Vélaz, María J.Garrido, Juan M. Benito, Conchita Tros de Ilarduya, Carmen Ortiz Mellett and Jose M. García Ferna
Published in: The 31st International Carbohydrate Symposium, 2024
Publisher: IIQ

Abstracts presented by Bicyclos authors at the 21th International Cyclodextrin Symposium in Dunkerque (FR)

Author(s): Manet, I., Piñeiro, Á., O'Connor, M., Sohajda, T., Anderson, A. M., Malanga, M., Benito, J. M., Béni, S., Kalydi, E., Sadrerafi, K., & Garcia Fandino, R
Published in: 21th International Cyclodextrin Symposium (ICS21), 2024
Publisher: Zenodo
DOI: 10.5281/ZENODO.11666512

Collection of Abstracts of plenaries presented by Bicyclos partners at VI International Summer School on Cyclodextrins, 2025 in Genova

Author(s): Ilse Manet, Milo Malanga, Erem Bilensoy, Jose Manuel Garcia Fernandez
Published in: VI International Summer School on Cyclodextrins 2025, 2025
Publisher: Zenodo
DOI: 10.5281/ZENODO.17175114

Enhancing Nucleic Acid Nanocomplexation with Cyclodextrin-Based Giant Bola-Amphiphile Molecules

Author(s): """Sergio Adorna-Sánchez, Gonzalo Rivero-Barbarroja, Theo Stahl, José López-Fernández, Inmaculada Juárez-Gonzálvez, Christophe Di Giorgio, Itziar Vélaz, María J. Garrido, Juan M. Benito, Conchita Tros de Ilarduya, Carmen Ortiz Mellet and José M. García Fern"
Published in: ChemBio VII, 2024
Publisher: IIQ

Cyclodextrins in Electrochemical Sensing: Innovations in Drugs and Metabolites Detection

Author(s): Casulli Maria Antonietta
Published in: Osaka University Lecture, 2024
Publisher: x11

Design and synthesis of cyclodextrin-based materials as multi-purpose supramolecular platforms

Author(s): Agnes Marco
Published in: XVI Congresso nazionale di Chimica Supramolecolare, 2024
Publisher: Zenodo
DOI: 10.5281/ZENODO.13748216

Advancing Nucleic Acid Therapeutics: Trehalose-Sucrose Macrocycles As Non-Viral Vectors

Author(s): José López-Fernández, Inmaculada Juárez-Gonzálvez, Itziar Vélaz, María J. Garrido, Juan M. Benito, Carlos Fernández-Clavero, Conchita Tros de Ilarduya, Francisco Mendicuti, Carmen Ortiz Mellet and José M. García Fernández
Published in: The 31st International Carbohydrate Symposium, 2024
Publisher: IIQ

"Cyclodextrin-Based ""Frustrated"" Amphipiles: One-Component, Cell-Selective Nucleic Acid Delivery Systems"

Author(s): José López-Fernández, Gonzalo Rivero-Barbarroja, Juan M. Benito, Inmaculada Juárez-Gonzálvez, Carlos Fernández-Clavero, Itziar Vélaz, María J. Garrido, Carmen Ortiz Mellet, Francisco Mendicuti, Conchita Tros de Ilarduya, José M. García Fernández.
Published in: 7th Iberian Carbohydrate Meeting, 2024
Publisher: IIQ

Elucidation of in vitro Characterization of Exosome and Liposome Based Nanovesicular Sorafenib Carrier Systems for Hepatocellular Carcinoma Treatment

Author(s): Varan Gamze, Demirtürk Nese, Dağ S., Şenel C., Bilensoy Erem
Published in: Training and Capacity Building for Enlargement and Integration Countries, Open Access to JRC Research Infrastructures, European Commission, 2024
Publisher: x10

Tailoring hierarchical self-assembling on carbohydrate templates: A versatile entry to the design of artificial viruses for gene delivery

Author(s): Juan M. Benito, Gonzalo Rivero-Barbarroja, José Lopez-Fernandez, José M. Garcia Fernandez, C. Ortiz Mellet
Published in: Annual Meeting of the Working Commettee for Csrbohydrates, Nucleic Acids and Antibiotics of the Hungarian Academy of Sciences, 2024
Publisher: IIQ

Cyclodextrin: Programming Sugars at the Nanoscale for Biomolecular Recognition and Delivery

Author(s): Jose M. García Fernàndez, Juan M. Benito, Carmen Ortiz Mellet
Published in: NanoBioMat 2023 - Winter Edition, 2023
Publisher: IIQ

Structure-, Valency-, and Stimuli-Responsive Glycomimetics in biology and medicine: targeting enzymes, lectins, and immune mediators

Author(s): C. Ortiz Mellet
Published in: 21st National Meeting of the Spanish Society of Medicinal Chemistru, 2025
Publisher: IIQ

Cyclodextrins for Electrochemical Sensors: Innovations and Solutions

Author(s): Casulli Maria Antonietta
Published in: Institute of Science Tokyo, 2024
Publisher: x12

Highlights of a journey with Cyclodextrins and Light  

Author(s): Ilse Gert Julia Manet
Published in: Italian Photochemistry Meeting 2023, 2023
Publisher: Zenodo
DOI: 10.5281/ZENODO.10519133

Exploiting azobenzene-cyclodextrin interactions for light-sensitive nucleic acid delivery.

Author(s): G. Rivero-Barbarroja, C. Fernández-Clavero, C. García-Iriepa, G. Marcelo, M. C. Padilla-Pérez, M. J. Puerto Madorrán, T. Neva, J. M. Benito, S. Maisonneuve, C. Ortiz Mellet, J. Xie, F. Mendicuti, J. M. García Fernández
Published in: 7th Iberian Carbohydrate Meeting, 2024
Publisher: IIQ

Collection of Abstracts of flash presentations presented by Bicyclos partners at VI International Summer School on Cyclodextrins, 2025 in Genova

Author(s): Sergio Adorna-Sanchez, Claudia Felicia Mautome, Julia Krakowiak, Ceren Senel, Oyku Simsekli, Dag Sena
Published in: VI International Summer School on Cyclodextrins, 2025
Publisher: Zenodo
DOI: 10.5281/ZENODO.17226811

Peer reviewed articles (18)

High‐Mannose Oligosaccharide Hemimimetics that Recapitulate the Conformation and Binding Mode to Concanavalin A, DC‐SIGN and Langerin

Author(s): Herrera‐gonzález, Irene; González‐cuesta, Manuel; Thépaut, Michel; Laigre, Eugénie; Goyard, David; Rojo, Javier; García Fernández, José; Fieschi, Franck; Renaudet, Olivier; Nieto, Pedro; Ortiz Mellet, Carmen
Published in: Chemistry – A European Journal, 2023, ISSN 1521-3765
Publisher: Wiley
DOI: 10.1002/CHEM.202303041

Cationic Cyclodextrin-Based Carriers for Drug and Nucleic Acid Delivery

Author(s): Adila Nazli, Milo Malanga, Tamás Sohajda, Szabolcs Béni
Published in: Pharmaceutics, Issue 17, 2025, ISSN 1999-4923
Publisher: MDPI AG
DOI: 10.3390/PHARMACEUTICS17010081

Trehalose-polyamine/DNA nanocomplexes: impact of vector architecture on cell and organ transfection selectivity

Author(s): Fernando Ortega-Caballero, María L. Santana-Armas, Conchita Tros de Ilarduya, Christophe Di Giorgio, Raphäel Tripier, Nathalie Le Bris, Cedric Ollier, Carmen Ortiz Mellet, José M. García Fernández, José L. Jiménez Blanco, Alejandro Méndez-Ardoy
Published in: Journal of Materials Chemistry B, Issue 12, 2024, ISSN 2050-750X
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D3TB02889E

β-Cyclodextrin-based geometrically frustrated amphiphiles as one-component, cell-specific and organ-specific nucleic acid delivery systems

Author(s): Gonzalo Rivero-Barbarroja, José López-Fernández, Inmaculada Juárez-Gonzálvez, Carlos Fernández-Clavero, Christophe Di Giorgio, Itziar Vélaz, María J. Garrido, Juan M. Benito, Carmen Ortiz Mellet, Francisco Mendicuti, Conchita Tros de Ilarduya, José M. García Fernández
Published in: Carbohydrate Polymers, Issue 347, 2024, ISSN 0144-8617
Publisher: Elsevier BV
DOI: 10.1016/J.CARBPOL.2024.122776

Cyclodextrin-Enabled Enantioselective Complexation Study of Cathinone Analogs

Author(s): András Dohárszky, Eszter Kalydi, Gergely Völgyi, Szabolcs Béni, Ida Fejős
Published in: Molecules, Issue 29, 2025, ISSN 1420-3049
Publisher: MDPI AG
DOI: 10.3390/MOLECULES29040876

From mother's milk to structural insights: 1H–15N NMR analysis of Lewis X antigen-bearing oligosaccharides isolated from human milk

Author(s): Garádi, Zsófia; Dancsó, András; Piskarev, Vladimir; Béni, Szabolcs
Published in: Carbohydrate Polymers, 2025, ISSN 1879-1344
Publisher: Elsevier Ltd
DOI: 10.1016/J.CARBPOL.2024.122534

Sculpturing the future of water-soluble cyclodextrin branched polymers in pharmaceutical applications

Author(s): Marco Agnes, Arianna Mazza, Milo Malanga, Ilse Manet
Published in: Journal of Materials Chemistry B, Issue 12, 2024, ISSN 2050-750X
Publisher: Royal Society of Chemistry (RSC)
DOI: 10.1039/D4TB01165A

Exceptional stability of the sugammadex-solasodine complex: Insights from experimental and theoretical studies

Author(s): Eszter Kalydi, Fanni Sebák, Béla Fiser, Babak Minofar, Éva Moussong, Milo Malanga, Andrea Bodor, József Kardos, Szabolcs Béni
Published in: Carbohydrate Polymers, Issue 348, 2024, ISSN 0144-8617
Publisher: Elsevier BV
DOI: 10.1016/J.CARBPOL.2024.122819

Cyclodextrins: Establishing building blocks for AI-driven drug design by determining affinity constants in silico

Author(s): Amelia Anderson; Ángel Piñeiro; Rebeca García-Fandiño; Matthew S. O’Connor
Published in: Computational and Structural Biotechnology Journal, 2024, ISSN 2001-0370
Publisher: Elsevier B.V.
DOI: 10.1016/J.CSBJ.2024.02.011

Chiral Recognition Mechanism of Benzyltetrahydroisoquinoline Alkaloids: Cyclodextrin-Mediated Capillary Electrophoresis, Chiral HPLC, and NMR Spectroscopy Study

Author(s): Erzsébet Várnagy, Gergő Tóth, Sándor Hosztafi, Máté Dobó, Ida Fejős, Szabolcs Béni
Published in: Molecules, Issue 30, 2025, ISSN 1420-3049
Publisher: MDPI AG
DOI: 10.3390/MOLECULES30051125

Understanding the mechanisms of enantiomer binding and recognition with cyclodextrins by integrating capillary electrophoresis, nuclear magnetic resonance and quantum mechanics

Author(s): Ani Rurua, Mariam Shanidze, Nutsa Tsetskhladze, Antonio Salgado, Paola Peluso, Roberto Dallocchio, Gerhard K.E. Scriba, Milo Malanga, Szabolcs Beni, Bezhan Chankvetadze
Published in: Carbohydrate Polymers, Issue 368, 2025, ISSN 0144-8617
Publisher: Elsevier BV
DOI: 10.1016/J.CARBPOL.2025.124173

Molecular encapsulation of the aminosteroid phytotoxins solanidine and α-solanine by sugammadex: new insights into atomic-level interactions

Author(s): Eszter Kalydi, Nikoletta Murvai, Emmanuel Saridakis, Irene M. Mavridis, Milo Malanga, József Kardos, Konstantina Yannakopoulou, Szabolcs Béni
Published in: Carbohydrate Polymers, 2025, ISSN 1879-1344
Publisher: Elsevier Ltd
DOI: 10.1016/J.CARBPOL.2025.123824

Folate Receptor β (FRβ) Expression on Myeloid Cells and the Impact of Reticuloendothelial System on Folate-Functionalized Nanoparticles’ Biodistribution in Cancer

Author(s): Sibel Goksen; Gamze Varan; Erem Bilensoy; Gunes Esendagli
Published in: Molecular Pharmaceutics, 2024, ISSN 1543-8392
Publisher: American Chemical Society
DOI: 10.1021/ACS.MOLPHARMACEUT.4C00663

Light-controlled assembly and disassembly of cyclodextrin-bisazobenzene supramolecular complexes

Author(s): Carlos Fernández-Clavero, Gonzalo Rivero-Barbarroja, Thais Carmona, Cristina García-Iriepa, Gema Marcelo, Conchita Tros de Ilarduya, Carmen Ortiz Mellet, José M. García Fernández, Juan M. Benito, Francisco Mendicuti
Published in: European Polymer Journal, Issue 229, 2025, ISSN 0014-3057
Publisher: Elsevier BV
DOI: 10.1016/J.EURPOLYMJ.2025.113849

Addressing the complexities in measuring cyclodextrin-sterol binding constants: A multidimensional study

Author(s): Amelia M. Anderson, Ilse Manet, Milo Malanga, Daniel M. Clemens, Keivan Sadrerafi, Ángel Piñeiro, Rebeca García-Fandiño, Matthew S. O'Connor
Published in: Carbohydrate Polymers, Issue 323, 2025, ISSN 0144-8617
Publisher: Elsevier BV
DOI: 10.1016/J.CARBPOL.2023.121360

Structure‐Based Design and in‐Flow Synthesis of Aromatic Endoperoxides Acting as Oxygen Releasing Agents

Author(s): Marco Agnes, Adelaide Santagata, Daniele Veclani, Alessandro Venturini, Magda Monari, Paolo Dambruoso, Ilse Manet
Published in: European Journal of Organic Chemistry, 2024, ISSN 1434-193X
Publisher: Wiley
DOI: 10.1002/EJOC.202400861

Cyclodextrin-Based Nanogels for Stabilization and Sensing of Curcumin

Author(s): Maria Antonietta Casulli, Ruyu Yan, Satomi Takeuchi, Andrea Cesari, Fabrizio Mancin, Takashi Hayashita, Takeshi Hashimoto, Irene Taurino
Published in: ACS Applied Nano Materials, Issue 7, 2025, ISSN 2574-0970
Publisher: American Chemical Society (ACS)
DOI: 10.1021/ACSANM.4C02972

Solving the puzzle of 2-hydroxypropyl β-cyclodextrin: Detailed assignment of the substituent distribution by NMR spectroscopy

Author(s): Kalydi, Eszter; Malanga, Milo; Nielsen, Thorbjørn Terndrup; Wimmer, Reinhard; Béni, Szabolcs
Published in: Carbohydrate Polymers, 2024, ISSN 1879-1344
Publisher: Elsevier Ltd
DOI: 10.1016/J.CARBPOL.2024.122167

Other (1)

Abstracts presented by Bicyclos authors at the 21th International Cyclodextrin Symposium in Dunkerque (FR)

Author(s): Manet, Ilse
Published in: 2024
DOI: 10.5281/ZENODO.11666511