Identification of subtype-specific biomarkers in small cell lung cancer

Project Information

BIOSMALL

Grant agreement ID: 101131228

DOI

10.3030/101131228

EC signature date 2 August 2023

Start date 1 October 2023

End date 30 September 2027

Funded under

• Marie Skłodowska-Curie Actions (MSCA)

Total cost

No data

EU contribution

€ 897 000,00

Coordinated by

MEDIZINISCHE UNIVERSITAET WIEN
Austria

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Completion of Website and Social Media Account

We will complete the website and social media account for public information.

Data Management Plan (1)

Data Management Plan

We will prepare the Data Management Plan (DMP) about the handling of research data.

Publications

Peer reviewed articles (12)

Deep Learning–Based Retinoblastoma Protein Subtyping of Pulmonary Large-Cell Neuroendocrine Carcinoma on Small Hematoxylin and Eosin–Stained Specimens

Author(s): Teodora E. Trandafir, Frank W.J. Heijboer, Farhan Akram, Jules L. Derks, Yunlei Li, Lisa M. Hillen, Ernst-Jan M. Speel, Zsolt Megyesfalvi, Balazs Dome, Andrew P. Stubbs, Anne-Marie C. Dingemans, Jan H. von der Thüsen
Published in: Laboratory Investigation, Issue 105, 2025, ISSN 0023-6837
Publisher: Elsevier BV
DOI: 10.1016/J.LABINV.2025.104192

Expression patterns of novel immunotherapy targets in intermediate- and high-grade lung neuroendocrine neoplasms

Author(s): Bence Ferencz, Klára Török, Orsolya Pipek, János Fillinger, Kristóf Csende, András Lantos, Radoslava Černeková, Marcel Mitták, Jozef Škarda, Patricie Delongová, Evelyn Megyesfalvi, Karin Schelch, Christian Lang, Anna Solta, Kristiina Boettiger, Luka Brcic, Jörg Lindenmann, Ferenc Rényi-Vámos, Clemens Aigner, Judit Berta, Zsolt Megyesfalvi, Balázs Döme
Published in: Cancer Immunology, Immunotherapy, Issue 73, 2024, ISSN 1432-0851
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/s00262-024-03704-7

Unveiling the powerhouse: ASCL1-driven small cell lung cancer is characterized by higher numbers of mitochondria and enhanced oxidative phosphorylation

Author(s): Solta, A; Ernhofer, B; Boettiger, K; Lang, C; Megyesfalvi, Z; Mendrina, T; Kirchhofer, D; Timelthaler, G; Szeitz, B; Rezeli, M; Aigner, C; Haschemi, A; Unger, LW; Dome, B; Schelch, K
Published in: Cancer & Metabolism, Issue 13, 2025, ISSN 2049-3002
Publisher: BMC
DOI: 10.1186/S40170-025-00382-6

Comprehensive biobanking strategy with clinical impact at the European Cancer Moonshot Lund Center

Author(s): Henriett Oskolas, Fábio C.N. Nogueira, Gilberto B. Domont, Kun-Hsing Yu, Yevgeniy R. Semenov, Peter Sorger, Erik Steinfelder, Les Corps, Lesley Schulz, Elisabet Wieslander, David Fenyö, Sarolta Kárpáti, Péter Holló, Lajos V. Kemény, Balazs Döme, Zsolt Megyesfalvi, Krzysztof Pawłowski, Toshihide Nishimura, HoJeong Kwon, Sergio Encarnación-Guevara, A. Marcell Szasz, Zoltán Veréb, Rolland Gyulai, István Balázs Németh, Roger Appelqvist, Melinda Rezeli, Bo Baldetorp, Peter Horvatovich, Johan Malmström, Indira Pla, Aniel Sanchez, Beatrice Knudsen, András Kiss, Johan Malm, György Marko-Varga, Jeovanis Gil
Published in: Journal of Proteomics, Issue 316, 2025, ISSN 1874-3919
Publisher: Elsevier BV
DOI: 10.1016/J.JPROT.2025.105442

Small cells – big issues: biological implications and preclinical advancements in small cell lung cancer

Author(s): Anna Solta, Büsra Ernhofer, Kristiina Boettiger, Zsolt Megyesfalvi, Simon Heeke, Mir Alireza Hoda, Christian Lang, Clemens Aigner, Fred R. Hirsch, Karin Schelch, Balazs Döme
Published in: Molecular Cancer, Issue 23, 2024, ISSN 1476-4598
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S12943-024-01953-9

Prophylactic cranial irradiation for small cell lung cancer in the era of immunotherapy and molecular subtypes

Author(s): Veronika Pozonec, Maria Dorothea Pozonec, Clemens Aigner, Joachim Widder, Kristiina Boettiger, Zsolt Megyesfalvi, Balazs Dome
Published in: Current Opinion in Oncology, Issue 37, 2024, ISSN 1040-8746
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/CCO.0000000000001111

Fibroblast growth factor signals drive the metastatic behavior in small cell lung cancer

Author(s): Büsra Ernhofer, Anna Solta, Julia Sinner, Zsolt Megyesfalvi, Abigail J. Deloria, Kristiina Boettiger, Lisa Glatt, Lilla Horvath, Caterina Sturtzel, Andrea Wenninger-Weinzierl, Martin Distel, Michael
Published in: British Journal of Cancer, 2025, ISSN 0007-0920
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41416-025-03276-Y

Expression of costimulatory molecule CD70 is prognostic in small cell lung cancer

Author(s): David Dora, Zsolt Megyesfalvi, Imre Vörös, Ágnes Paál, Peter Takacs, Daniela Dobos, Bence Lőrincz, Syeda Mahak Zahra Bokhari, Kenan Aloss, Gergely Pallag, Christopher Rivard, Hui Yu, Fred R. Hirsch, Anikó Görbe, Zoltán V. Varga, Zoltan Lohinai, Balazs Dome
Published in: Cancer Immunology, Immunotherapy, Issue 74, 2025, ISSN 1432-0851
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S00262-025-04006-2

Comparative profiling of surgically resected primary tumors and their lymph node metastases in small-cell lung cancer

Author(s): K. Csende, B. Ferencz, K. Boettiger, M.D. Pozonec, A. Lantos, A. Ferenczy, O. Pipek, A. Solta, B. Ernhofer, V. Laszlo, E. Megyesfalvi, K. Schelch, V. Pozonec, J. Skarda, V. Skopelidou, Z. Lohinai, C. Lang, L. Horvath, K. Dezso, J. Fillinger, F. Renyi-Vamos, C. Aigner, B. Dome, Z. Megyesfalvi
Published in: ESMO Open, Issue 10, 2025, ISSN 2059-7029
Publisher: Elsevier BV
DOI: 10.1016/J.ESMOOP.2025.104514

C-Myc protein expression indicates unfavorable clinical outcome in surgically resected small cell lung cancer

Author(s): Christian Lang, Zsolt Megyesfalvi, Andras Lantos, Felicitas Oberndorfer, Mir Alireza Hoda, Anna Solta, Bence Ferencz, Janos Fillinger, Anna Solyom-Tisza, Alessandro Saeed Querner, Felix Egger, Kristiina Boettiger, Thomas Klikovits, Gerald Timelthaler, Ferenc Renyi-Vamos, Clemens Aigner, Konrad Hoetzenecker, Viktoria Laszlo, Karin Schelch, Balazs Dome
Published in: World Journal of Surgical Oncology, Issue 22, 2024, ISSN 1477-7819
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S12957-024-03315-7

Small Particles, Big Problems: Polystyrene nanoparticles induce DNA damage, oxidative stress, migration, and mitogenic pathways predominantly in non-malignant lung cells

Author(s): Büsra Ernhofer, Andreas Spittler, Franziska Ferk, Miroslav Mišík, Martha Magdalena Zylka, Lisa Glatt, Kristiina Boettiger, Anna Solta, Dominik Kirchhofer, Gerald Timelthaler, Zsolt Megyesfalvi, Verena Kopatz, Heinrich Kovar, Siegfried Knasmueller, Clemens Aigner, Lukas Kenner, Balazs Döme, Karin Schelch
Published in: Journal of Hazardous Materials, Issue 495, 2025, ISSN 0304-3894
Publisher: Elsevier BV
DOI: 10.1016/J.JHAZMAT.2025.139129

Small Cell Lung Cancer Classification: Unraveling Heterogeneity to Enable Personalized Treatments

Author(s): Kristiina Boettiger, Ildikó Kovács, Lilla Horvath, Büsra Ernhofer, Karin Schelch, Maria Dorothea Pozonec, Vivien Teglas, Clemens Aigner, Evelyn Megyesfalvi, Ferenc Rényi-Vámos, Krisztina Bogos, Christian Lang, Abigail J. Deloria, Carl M. Gay, Lauren A. Byers, Julien Sage, Fred R. Hirsch, Zsolt Megyesfalvi, Balazs Dome
Published in: Cancer Research, 2025, ISSN 0008-5472
Publisher: American Association for Cancer Research (AACR)
DOI: 10.1158/0008-5472.CAN-25-1483