Objective
"This project aims to create a multi-scale patient-specific human virtual twin for patients who are eligible for CAR T cell therapy, which can be extended to cellular immunotherapies in general. The virtual twin will be fully integrated into the ecosystem under the Digital Europe Programme and will be available as a research-use-only prototype in relevant application environments with technology readiness level 6. The virtual twin will support decision-making throughout the patient's journey, from diagnosis to pre-treatments, cellular immunotherapy, and late patient monitoring. This will enable patients and health experts to identify the most effective course of therapy.
The virtual twin for cellular immunotherapies will take multi-scale modelling to the next level by providing methodological concepts for integrating ""living drugs"" such as CAR T cells into the human virtual twin ecosystem.
To achieve this goal, the project builds on existing data models for hematological malignancies and multiple myeloma (MM) to create a virtual twin for CAR T cell therapy for MM patients. The implementation process follows software development principles for software as medical devices, ensuring the exploitation of the research-use-only prototype. Patient's, SSH, gender differences, and other stakeholders' perspectives are fully integrated into the design, specification, and implementation process.
Throughout the implementation process, a modular software architecture and extensible ontologies/terminologies are utilized, making the reference model easily transferable to other indications that can be treated with CAR T cell therapy or other cellular immunotherapies. Overall, the CERTAINTY virtual twin will provide decision support for patients and health experts, improving the effectiveness of cellular immunotherapies and advancing precision medicine."
Fields of science
- natural sciencescomputer and information sciencessoftwaresoftware development
- medical and health scienceshealth sciencespersonalized medicine
- natural sciencesbiological sciencesecologyecosystems
- medical and health sciencesbasic medicineimmunologyimmunotherapy
- medical and health sciencesmedical biotechnologycells technologies
Keywords
Programme(s)
Funding Scheme
HORIZON-RIA - HORIZON Research and Innovation ActionsCoordinator
80686 Munchen
Germany
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Participants (14)
04109 Leipzig
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51105 Cologne
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
81677 MUNCHEN
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
1050 BRUXELLES
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79098 Freiburg
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601 77 Brno
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4354 ESCH SUR ALZETTE
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
97080 Wurzburg
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75231 Paris
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5000 Namur
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3584 CX Utrecht
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10117 Berlin
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2333 AA Leiden
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84043 LEHI
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
Partners (1)
4070 Basel
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