A CEllulaR immunoTherapy virtuAl twin for personalIsed cancer treatmeNT

Project Information

CERTAINTY

Grant agreement ID: 101136379

DOI

10.3030/101136379

EC signature date 11 December 2023

Start date 1 December 2023

End date 31 May 2028

Funded under

• Health

Total cost

€ 10 060 452,50

EU contribution

€ 9 999 252,50

Coordinated by

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Project website

Website presenting the project to the general public

Data Management Plan (1)

Data Quality Management Plan

1st version of plan describing the steps, measurements, and KPIs for assuring the project's utilization of high quality data (will be continuously updated)

Documents, reports (3)

Plan for dissemination, communication & exploitation

Report detailing the plan for dissemination & communication

"FAIR ""cookbook"""

Description of FAIRification methods for the project released

1st stakeholder workshop

Multi-disciplinary, multi-initiative, and multi-stakeholder workshop to revise specified VT requirements

Publications

Peer reviewed articles (11)

Emerging T-cell lymphomas after CAR T-cell therapy

Author(s): Till Braun, Florian Kuschel, Kristin Reiche, Maximilian Merz, Marco Herling
Published in: Leukemia, Issue 39, 2025, ISSN 0887-6924
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41375-025-02574-X

Remission conversion drives outcomes after CAR T-cell therapy for multiple myeloma: a registry analysis from the DRST

Author(s): Maximilian Merz, Nico Gagelmann, Samih Smaili, Sarah Flossdorf, Sandra Sauer, Christof Scheid, Bastian von Tresckow, Gerald Georg Wulf, Katja C Weisel, Igor Blau, Monika Engelhardt, Ralph Wäsch, Natalie Schub, Raphael Teipel, Judith S. Hecker, Johannes M. Waldschmidt, Britta Besemer, Ben-Niklas Baermann, Simon Call, Leo Hansmann, Francis Ayuketang Ayuk, Marc S. Raab, Hermann Einsele, Uwe Platzbecker, Nicolaus Kröger
Published in: Blood Journal, 2025, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/BLOOD.2025028330

Building multiscale models with PhysiBoSS, an agent-based modeling tool

Author(s): Marco Ruscone, Andrea Checcoli, Randy Heiland, Emmanuel Barillot, Paul Macklin, Laurence Calzone, Vincent Noël
Published in: Briefings in Bioinformatics, Issue 25, 2024, ISSN 1467-5463
Publisher: Oxford University Press (OUP)
DOI: 10.1093/BIB/BBAE509

Virtual twins for personalised CAR T-cell therapy in myeloma

Author(s): Kristin Reiche, Ulrike Weirauch, Markus Kreuz, Luise Fischer, Luuk Gras, Thomas Neumuth, Uwe Platzbecker, Ulrike Köhl, Regina Demlova, Andreas Kremer, Holger Fröhlich, Stefan Franke, Maximilian Merz, Colin Birkenbihl, Miriam Alb, Maria Quaranta, Laurence Calzone, Sophia Orozco-Ruiz, Stefanie Binder, Solène Clavreul, Morine Maguri, Maximilian Ferle, Michael Rade, Guillaume Azarias, Jay R. Hydren, Jakub Jamarik, Daniel Schwarz, Zsolt Sebastyen, Jurgen Kuball, Georg Popp, Chloé Antoine, Manon Knockaert, Clara T. Schoeder, David Fandrei, Carmen Sanges, Vaclovas Radvilas, Nico Gagelmann, Markus Rückert, Olaf Penack, Stephan Fricke, Andreas Schmidt, Carol Ward, Carl Steinbeisser, Jean-Marc Van Gyseghem, Anna Niarakis, Laurent Garderet, Michael Hudecek
Published in: The Lancet Haematology, Issue 12, 2025, ISSN 2352-3026
Publisher: Elsevier BV
DOI: 10.1016/S2352-3026(25)00170-X

Immune digital twins for complex human pathologies: applications, limitations, and challenges

Author(s): Anna Niarakis, Reinhard Laubenbacher, Gary An, Yaron Ilan, Jasmin Fisher, Åsmund Flobak, Kristin Reiche, María Rodríguez Martínez, Liesbet Geris, Luiz Ladeira, Lorenzo Veschini, Michael L. Blinov, Francesco Messina, Luis L. Fonseca, Sandra Ferreira, Arnau Montagud, Vincent Noël, Malvina Marku, Eirini Tsirvouli, Marcella M. Torres, Leonard A. Harris, T. J. Sego, Chase Cockrell, Amanda E. Shick, Hasan Balci, Albin Salazar, Kinza Rian, Ahmed Abdelmonem Hemedan, Marina Esteban-Medina, Bernard Staumont, Esteban Hernandez-Vargas, Shiny Martis B, Alejandro Madrid-Valiente, Panagiotis Karampelesis, Luis Sordo Vieira, Pradyumna Harlapur, Alexander Kulesza, Niloofar Nikaein, Winston Garira, Rahuman S. Malik Sheriff, Juilee Thakar, Van Du T. Tran, Jose Carbonell-Caballero, Soroush Safaei, Alfonso Valencia, Andrei Zinovyev, James A. Glazier
Published in: npj Systems Biology and Applications, Issue 10, 2024, ISSN 2056-7189
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41540-024-00450-5

Single-cell multiomic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed multiple myeloma

Author(s): Michael Rade, Nora Grieb, Ronald Weiss, Jaren Sia, Luise Fischer, Patrick Born, Andreas Boldt, Stephan Fricke, Paul Franz, Jonathan Scolnick, Lakshmi Venkatraman, Stacy Xu, Christina Kloetzer, Simone Heyn, Anne Sophie Kubasch, Ronny Baber, Song Yau Wang, Enrica Bach, Sandra Hoffmann, Jule Ussmann, Birthe Schetschorke, Saskia Hell, Sebastian Schwind, Klaus H. Metzeler, Marco Herling, Madlen Jentzsch, Georg-Nikolaus Franke, Ulrich Sack, Ulrike Köhl, Uwe Platzbecker, Kristin Reiche, Vladan Vucinic, Maximilian Merz
Published in: Nature Cancer, Issue 5, 2024, ISSN 2662-1347
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S43018-024-00763-8

Prognostic implications of splenomegaly in BCMA-directed CAR T-Cell therapy for relapsed myeloma

Author(s): Thomas Wiemers, Maximilian Ferle, Jonas Ader, Veronika Sotikova, David Fandrei, Nora Grieb, Luise Fischer, Patrick Born, Heike Weidner, Song Yau Wang, Madlen Jentzsch, Georg-Nikolaus Franke, Carmen Herling, Klaus Metzeler, Marco Herling, Simone Heyn, Timm Denecke, Kristin Reiche, Uwe Platzbecker, Vladan Vucinic, Thomas Neumuth, Hans-Jonas Meyer, Maximilian Merz
Published in: Transplantation and Cellular Therapy, 2025, ISSN 2666-6367
Publisher: Elsevier BV
DOI: 10.1016/J.JTCT.2025.07.003

Bispecific Antibodies as Bridging to BCMA CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma

Author(s): David Fandrei, Sabine Seiffert, Michael Rade, Susanne Rieprecht, Nico Gagelmann, Patrick Born, Thomas Wiemers, Heike Weidner, Markus Kreuz, Tamara Schassberger, Jannik Koßmann, Marlene Mangold, Daniel Fürst, Luise Fischer, Ronny Baber, Simone Heyn, Song Yau Wang, Enrica Bach, Sandra Hoffmann, Klaus H. Metzeler, Marco Herling, Madlen Jentzsch, Georg-Nikolaus Franke, Ulrike Köhl, Maik Friedrich, Andreas Boldt, Kristin Reiche, Uwe Platzbecker, Vladan Vucinic, Maximilian Merz
Published in: Blood Cancer Discovery, Issue 6, 2025, ISSN 2643-3230
Publisher: American Association for Cancer Research (AACR)
DOI: 10.1158/2643-3230.BCD-24-0118

Multiomic profiling of T cell lymphoma after therapy with anti-BCMA CAR T cells and GPRC5D-directed bispecific antibody

Author(s): Till Braun, Michael Rade, Maximilian Merz, Hanna Klepzig, Florian Große, David Fandrei, Nhu-Nguyen Pham, Markus Kreuz, Christina Katharina Kuhn, Florian Kuschel, Dennis Löffler, Jörn Meinel, Eva Heger, Viola Schweinsberg, Natali Pflug, Uwe Platzbecker, Michael Hallek, Udo Holtick, Ulrike Köhl, Christof Scheid, Kristin Reiche, Marco Herling, Tim Richardson
Published in: Nature Medicine, Issue 31, 2025, ISSN 1078-8956
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41591-025-03499-9

Predicting progression events in multiple myeloma from routine blood work

Author(s): Maximilian Ferle, Nora Grieb, Markus Kreuz, Jonas Ader, Hartmut Goldschmidt, Elias K. Mai, Uta Bertsch, Uwe Platzbecker, Thomas Neumuth, Kristin Reiche, Alexander Oeser, Maximilian Merz
Published in: npj Digital Medicine, Issue 8, 2025, ISSN 2398-6352
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41746-025-01636-9

Prognostic significance of PET/CT for CAR T cell therapy in relapsed/refractory multiple myeloma

Author(s): Patrick Born, David Fandrei, Song Yau Wang, Carmen Perez‐Fernandez, Luise Fischer, Jule Ussmann, Enrica Bach, Sandra Hoffmann, Klaus H. Metzeler, Marco Herling, Carmen Herling, Madlen Jentzsch, Andreas Boldt, Sabine Seiffert, Ronny Baber, Heike Weidner, Georg‐Nikolaus Franke, Timm Denecke, Osama Sabri, Uwe Platzbecker, Vladan Vucinic, Hans Jonas Meyer, Lars Kurch, Maximilian Merz
Published in: HemaSphere, Issue 9, 2025, ISSN 2572-9241
Publisher: Wiley
DOI: 10.1002/HEM3.70159