EP PerMed is a European Partnership dedicated to Personalised Medicine (PM). It supports PM-related R&I, but also facilitates and accelerates all steps so that PM achievements successfully pass through the full value continuum to be implemented in sustainable health systems for the benefit of people and societies. EP PerMed fosters demonstration projects and promotes successes and lessons learned to demonstrate evidence of PM implementation. The partnership’s activities cover overarching aspects, like patient involvement, exchange with medical societies, infrastructures and international and regional collaboration. The project portfolios of EP PerMed and ERA PerMed (former ERA-Net co-fund on PM) and others are supported to become successful innovations in healthcare practice on national, regional or local level. EP PerMed will be the global PM-platform for scientific and strategic dialogue and alignment, resulting in public documents and publications. Accordingly, the partnership informs and engages the public, patients, healthcare providers or payers about the latest PM options. The Strategic Research and Innovation Agenda for Personalised Medicine (SRIA for PM, 2023), developed by the EP PerMed partners and supported by the International Consortium for Personalised Medicine (ICPerMed), is the basis for the partnership's structure and a wide range of its activities. All steps of the SRIA development were strongly supported by numerous PM-experts, stakeholders and the European Commission (EC). Thus, the EP PerMed annual Joint Transnational Calls (JTCs) and other funding activities, events and tools are in line with the SRIA and the outputs will feed into a SRIA update in the coming years. The partnership builds on several developments, initiatives and projects such as ERA PerMed, ICPerMed and its supporting projects (“ICPerMed Family”) funded by the EC. In parallel, it reaches out to the 1+Million Genomes Initiative, other European Partnerships in the Health Cluster and beyond, as well as to European and national infrastructures, like the European Strategy Forum on Research Infrastructures (ESFRI).