Project description
New kits and devices shed light on lipid transport in health and disease
The transport of lipids in the human body is essential to many processes, including energy storage, hormone regulation and nutrient transport. Its dysregulation is implicated in numerous disorders affecting the cardiovascular system, liver and lungs. It also plays an interrelated role in pathologies such as diabetes, cancer, inflammatory conditions and neurodegenerative diseases. Understanding lipid transport in health and disease is hindered by technological barriers to studying it. The ERC-funded AURORA project plans to upscale its current protocols to high-throughput screening set-ups. These will be implemented in ready-to-use kits and devices enabling academic laboratories and the pharmaceutical industry to address many important questions in lipid transport for the first time.
Objective
Dysregulation of lipid transport and metabolism is at the center of many diseases. Despite its crucial role, gaining a full understanding of lipid transport remains challenging as visualizing lipids and their transport by microscopy is almost impossible. By providing technological solutions to this problem, we envision to enable new therapeutic strategies with the corresponding benefits for society at large. A better understanding of lipid transport can help guide the design of drugs to for example treat fatty liver disease, which is estimated to affect up to quarter of the global population. During the ERC PoC grant period, we plan to translate our current protocols to high throughput screening setups with the goal to service the pharmaceutical industry and design ready-to-use kits and devices that will allow academic laboratories to answer their unique research questions.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences optics microscopy
- natural sciences biological sciences biochemistry biomolecules lipids
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-POC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.