Causes and consequences of aberrant mRNA translation in cancer

Project Information

pepTalks

Grant agreement ID: 101141245

DOI

10.3030/101141245

EC signature date 24 May 2024

Start date 1 September 2024

End date 31 August 2029

Funded under

• European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (1)

Data Management Plan

Drafting of Data Management Plan

Publications

Peer reviewed articles (10)

Proteome diversification by mRNA translation in cancer

Author(s): Adva Kochavi, Domenica Lovecchio, William James Faller, Reuven Agami
Published in: Molecular Cell, Issue 83, 2025, ISSN 1097-2765
Publisher: Elsevier BV
DOI: 10.1016/J.MOLCEL.2022.11.014

Adoptive T cell therapy targeting an inducible and broadly shared product of aberrant mRNA translation

Author(s): Julien Champagne, Morten M. Nielsen, Xiaodong Feng, Jasmine Montenegro Navarro, Abhijeet Pataskar, Rhianne Voogd, Lisanne Giebel, Remco Nagel, Nadine Berenst, Amos Fumagalli, Adva Kochavi, Domenica Lovecchio, Lorenzo Valcanover, Yuval Malka, Weiwen Yang, Maarja Laos, Yingqian Li, Natalie Proost, Marieke van de Ven, Olaf van Tellingen, Onno B. Bleijerveld, John B.A.G. Haanen, Johanna Olweus, Reuven Agami
Published in: Immunity, Issue 58, 2026, ISSN 1074-7613
Publisher: Elsevier BV
DOI: 10.1016/J.IMMUNI.2024.12.004

Arginine Deprivation of ASS1-Deficient Cancers Drives Mistranslation and Shared Neoepitope Production

Author(s): Remco Nagel, Adva Kochavi, Karine Flem-Karlsen, Mrittika Adhikary, Yali Gal-On, Maria G. Klaoudatou, Julien Champagne, Lorenzo Valcanover, Heyilimu Palashati, Morten M. Nielsen, Xiaodong Feng, Pierre-Rene Körner, Lisanne Giebel, Weiwen Yang, Arno Velds, Liesbeth Hoekman, Onno B. Bleijerveld, Olaf van Tellingen, Johanna Olweus, Reuven Agami
Published in: Cancer Research, Issue 86, 2026, ISSN 0008-5472
Publisher: American Association for Cancer Research (AACR)
DOI: 10.1158/0008-5472.CAN-25-4773

Histidine to glutamine substitutants, a regulated process that impacts cell survival and suggests histidine shortage in cancer

Author(s): Domenica Lovecchio, Pierre-René Körner, Lorenzo Valcanover, Onno B. Bleijerveld, Bart R. J. Blokhuis, Abhijeet Pataskar, Jasmine Montenegro Navarro, Demi Wernaart, Liesbeth Hoekman, Daniil Anastasopoulos, Kim Vrijland, Xiaodong Feng, Julien Champagne, Karin E. de Visser, Olaf van Tellingen, Frank A. Redegeld, Reuven Agami
Published in: Cell Death Discovery, 2026, ISSN 2058-7716
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41420-026-03225-5

Chemotherapeutic agents and leucine deprivation induce codon-biased aberrant protein production in cancer

Author(s): Adva Kochavi, Remco Nagel, Pierre-Rene Körner, Onno B Bleijerveld, Chun-Pu Lin, Zowi Huinen, Yuval Malka, Natalie Proost, Marieke van de Ven, Xiaodong Feng, Jasmine Montenegro Navarro, Abhijeet Pataskar, Daniel S Peeper, Julien Champagne, Reuven Agami
Published in: Nucleic Acids Research, Issue 52, 2024, ISSN 0305-1048
Publisher: Oxford University Press (OUP)
DOI: 10.1093/NAR/GKAE1110

Upstream open reading frame translation enhances immunogenic peptide presentation in mitotically arrested cancer cells

Author(s): Alexander Kowar, Jonas P. Becker, Rossella Del Pizzo, Zhiwei Tang, Julien Champagne, Kathrin Wellach, Kiana Samimi, Ariel Galindo-Albarrán, Pierre-René Körner, Jasmine Montenegro Navarro, Andrés Elía, Fiona Megan Tilghman, Hanan Sakeer, Marco Antonio Mendoza-Parra, Angelika B. Riemer, Reuven Agami, Fabricio Loayza-Puch
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-63405-2

ABPEPserver: a web application for documentation and analysis of substitutants

Author(s): Abhijeet Pataskar, Jasmine Montenegro Navarro, Reuven Agami
Published in: BMC Cancer, Issue 23, 2023, ISSN 1471-2407
Publisher: Springer Science and Business Media LLC
DOI: 10.1186/S12885-023-10970-8

DNA damage induces p53-independent apoptosis through ribosome stalling

Author(s): Nicolaas J. Boon, Rafaela A. Oliveira, Pierré-René Körner, Adva Kochavi, Sander Mertens, Yuval Malka, Rhianne Voogd, Suzanne E. M. van der Horst, Maarten A. Huismans, Lidwien P. Smabers, Jonne M. Draper, Lodewyk F. A. Wessels, Peter Haahr, Jeanine M. L. Roodhart, Ton N. M. Schumacher, Hugo J. Snippert, Reuven Agami, Thijn R. Brummelkamp
Published in: Science, Issue 384, 2024, ISSN 0036-8075
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIENCE.ADH7950

Exploiting nanopore sequencing advances for tRNA sequencing of human cancer models

Author(s): Adva Kochavi, Arno Velds, Maya Suzuki, Shinichiro Akichika, Tsutomu Suzuki, Roderick L Beijersbergen, Reuven Agami
Published in: NAR Cancer, Issue 7, 2025, ISSN 2632-8674
Publisher: Oxford University Press (OUP)
DOI: 10.1093/NARCAN/ZCAF044

Arginine deprivation enriches lung cancer proteomes with cysteine by inducing arginine-to-cysteine substitutants

Author(s): Chao Yang, Abhijeet Pataskar, Xiaodong Feng, Jasmine Montenegro Navarro, Inés Paniagua, Jacqueline J.L. Jacobs, Esther A. Zaal, Celia R. Berkers, Onno B. Bleijerveld, Reuven Agami
Published in: Molecular Cell, Issue 84, 2026, ISSN 1097-2765
Publisher: Elsevier BV
DOI: 10.1016/J.MOLCEL.2024.04.012