Mutations of mtDNA - inheriting without perishing

Project Information

TransMit

Grant agreement ID: 101141290

DOI

10.3030/101141290

EC signature date 24 May 2024

Start date 1 October 2024

End date 30 September 2029

Funded under

• European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

KAROLINSKA INSTITUTET
Sweden

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (6)

POLRMT overexpression increases mtDNA transcription without affecting steady-state mRNA levels

Author(s): Maria Miranda; Andrea Mesaros; Nathalie Scrima; Louise Pérard; Irina Kuznetsova; Martin Purrio; Ilian Atanassov; Aleksandra Filipovska; Arnaud Mourier; Nils-Göran Larsson; Inge Kühl
Published in: Life Science Alliance, 2025, ISSN 2575-1077
Publisher: Life Science Alliance, LLC
DOI: 10.26508/LSA.202302563

Older age reduces mtDNA mutation inheritance

Author(s): Polyxeni Papadea, Nils-Göran Larsson
Published in: Nature Aging, Issue 4, 2024, ISSN 2662-8465
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S43587-024-00701-4

In vivo composition of the mitochondrial nucleoid in mice

Author(s): Rodolfo García-Villegas, Franka Odenthal, Yvonne Giannoula, Nina A. Bonekamp, Inge Kühl, Chan Bae Park, Henrik Spåhr, Elisa Motori, Fredrik Levander, Nils-Göran Larsson
Published in: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Issue 1872, 2025, ISSN 0167-4889
Publisher: Elsevier BV
DOI: 10.1016/J.BBAMCR.2025.119955

The mitochondrial protein TMEM177 fine-tunes mammalian cytochrome c oxidase assembly

Author(s): Jakob D. Busch, Thomas Schöndorf, Dusanka Milenkovic, Xinping Li, Rolf Wibom, Joana F. Silva-Rodrigues, Roberta Filograna, Camilla Koolmeister, Nils-Göran Larsson, Diana Rubalcava-Gracia
Published in: Mitochondrion, Issue 86, 2026, ISSN 1567-7249
Publisher: Elsevier BV
DOI: 10.1016/J.MITO.2025.102099

Purifying selection during maternal inheritance of mammalian mtDNA depends on autophagy and bottleneck size

Author(s): Polyxeni Papadea, Nils-Göran Larsson
Published in: Autophagy, 2026, ISSN 1554-8627
Publisher: Informa UK Limited
DOI: 10.1080/15548627.2026.2650772

The bottleneck for maternal transmission of mtDNA is linked to purifying selection by autophagy

Author(s): Laura S. Kremer, Zoe Golder, Tom Barton-Owen, Polyxeni Papadea, Camilla Koolmeister, Patrick F. Chinnery, Nils-Göran Larsson
Published in: Science Advances, Issue 11, 2025, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCIADV.AEA4660