Acquired adaptive immune cell dysfunction and restoration in chronic hepatitis B

Project Information

EUCLIDEAN

Grant agreement ID: 101141363

DOI

10.3030/101141363

EC signature date 28 June 2024

Start date 1 September 2024

End date 31 August 2029

Funded under

• European Research Council (ERC)

Total cost

€ 2 500 000,00

EU contribution

€ 2 500 000,00

Coordinated by

UNIVERSITA VITA-SALUTE SAN RAFFAELE
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

Intrahepatic immunity to hepatitis B virus

Author(s): Valentina Venzin, Cristian G. Beccaria, Francesco Andreata, Valeria Fumagalli, Matteo Iannacone
Published in: Journal of Hepatology, Issue 81, 2026, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/J.JHEP.2024.05.029

Kupffer cells in liver homeostasis and disease: from immune sentinels to metabolic gatekeepers

Author(s): Bruna Araujo David, Francesco Andreata, Camille Blériot, Florent Ginhoux, Paul Kubes, Matteo Iannacone
Published in: Nature Reviews Immunology, Issue 26, 2026, ISSN 1474-1733
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41577-026-01288-0

Reframing IL-27: a central regulator of CD8+ T cell immunity

Author(s): Valentina Venzin, Matteo Iannacone
Published in: Trends in Immunology, Issue 47, 2026, ISSN 1471-4906
Publisher: Elsevier BV
DOI: 10.1016/J.IT.2025.10.012

Therapeutic potential of co-signaling receptor modulation in hepatitis B

Author(s): Francesco Andreata, Chiara Laura, Micol Ravà, Caroline C. Krueger, Xenia Ficht, Keigo Kawashima, Cristian G. Beccaria, Federica Moalli, Bianca Partini, Valeria Fumagalli, Giulia Nosetto, Pietro Di Lucia, Ilaria Montali, José M. Garcia-Manteiga, Elisa B. Bono, Leonardo Giustini, Chiara Perucchini, Valentina Venzin, Serena Ranucci, Donato Inverso, Marco De Giovanni, Marco Genua, Renato Ostuni, Enrico Lugli, Masanori Isogawa, Carlo Ferrari, Carolina Boni, Paola Fisicaro, Luca G. Guidotti, Matteo Iannacone
Published in: Cell, Issue 187, 2026, ISSN 0092-8674
Publisher: Elsevier BV
DOI: 10.1016/J.CELL.2024.05.038

Understanding local immunity to enable regionalized medicine

Author(s): Marco De Giovanni, Donato Inverso, Matteo Iannacone
Published in: The EMBO Journal, Issue 43, 2026, ISSN 1460-2075
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S44318-024-00255-6

Priming and Maintenance of Adaptive Immunity in the Liver

Author(s): Keigo Kawashima, Francesco Andreata, Cristian Gabriel Beccaria, Matteo Iannacone
Published in: Annual Review of Immunology, Issue 42, 2025, ISSN 0732-0582
Publisher: Annual Reviews
DOI: 10.1146/ANNUREV-IMMUNOL-090122-041354

Unlocking CD8+ T cell potential in chronic hepatitis B virus infection

Author(s): Valeria Fumagalli, Matteo Iannacone
Published in: Nature Reviews Gastroenterology & Hepatology, Issue 22, 2025, ISSN 1759-5045
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41575-024-01015-X

CD4+ T cells license Kupffer cells to reverse CD8+ T cell dysfunction induced by hepatocellular priming

Author(s): Valentina Venzin, Cristian G. Beccaria, Chiara Perucchini, Pietro Delfino, Elisa B. Bono, Leonardo Giustini, Federica Moalli, Marta Grillo, Valeria Fumagalli, Chiara Laura, Pietro Di Lucia, Katharina Reinhard, Jutta Petschenka, Tana Annmarie Omokoko, Anna Celant, Sabrina Ottolini, Keigo Kawashima, Micol Ravà, Marco De Giovanni, Donato Inverso, Mirela Kuka, Patrick T. F. Kennedy, Martin Guilliams, Giulia Casorati, Federica Pedica, Maurilio Ponzoni, Uğur Şahin, Nina Le Bert, Antonio Bertoletti, Fulvia Vascotto, Luca G. Guidotti, Matteo Iannacone
Published in: Nature Immunology, Issue 26, 2025, ISSN 1529-2908
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41590-025-02199-3

Beyond exhaustion: the unique characteristics of CD8+ T cell dysfunction in chronic HBV infection

Author(s): Robert Thimme, Antonio Bertoletti, Matteo Iannacone
Published in: Nature Reviews Immunology, Issue 24, 2024, ISSN 1474-1733
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41577-024-01097-3

The hidden strength of CD8+ T cells in chronic hepatitis B

Author(s): Francesco Andreata, Matteo Iannacone
Published in: Nature Immunology, Issue 25, 2026, ISSN 1529-2908
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41590-024-01939-1