Project description
Innovative treatment of myocardial infarction
Ischemic Heart Disease causes over 1.7 million deaths annually in the EU, primarily due to heart attacks (Myocardial Infarction - MI). Following a heart attack, heart failure (HF) affects over 26 million people globally. While current treatments save lives, they can also cause additional heart damage through inflammatory reactions. The EIC-funded CardioProtectMI project will evaluate the clinical effectiveness of RTP-026 through a Phase IIa proof-of-principle study and a Phase IIb proof-of-concept study. RTP-026 aims to modulate the immune system and reduce inflammation triggered by MI, thereby minimising heart damage and lowering the risk of HF and death. Preclinical data suggests that RTP-026 could reduce post-heart attack HF by over 20 %.
Objective
Ischemic Heart Disease kills more than 1.7M people/year in the EU, the vast majority via a heart attack (Myocardial Infarction - MI). Heart failure (HF) is the major cause of death after MI with a prevalence of >26M individuals globally. While current treatment involving restoration of blood flow to the heart saves the MI patients life it also causes additional damage to the heart through an inflammatory reaction (reperfusion injury).
ResoThers leading drug candidate, RTP-026, is an immunomodulating therapeutic aimed at resolving inflammation triggered during MI, thereby reducing damage to the heart and significantly decreasing risk of HF and death. Pre-clinical data suggests RTP-026 could reduce post-MI HF by >20%. A Phase I study has been conducted to determine safety and tolerability of RTP-026 in Healthy Volunteers. With the EIC we aim to validate RTP-026 clinical effectiveness by means of a Phase IIa patient proof of principle study and Phase IIb proof of concept study.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.3.1 - The European Innovation Council (EIC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-EIC-ACC-BF - HORIZON EIC Accelerator Blended Finance
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-EIC-2023-ACCELERATOR-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2840 Holte
Denmark
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.