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CORDIS - Resultados de investigaciones de la UE
CORDIS

Efficacy and Safety of a newly registered Artemisinin-Based Combination (Pyronaridine-Artesunate -PYRAMAX®) for the treatment of uncomplicated malaria in African pregnant women - Extended

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Website update (se abrirá en una nueva ventana)

Update website with Pyrapreg extension overview and consortium; website will subsequently be updated in M3, 6, 9 and 12.

Organization of project progress and final meeting(s) (se abrirá en una nueva ventana)

Meetings + minutes (either through monthly teleconference of face-to-face meetings) to monitor the implementation and progress of the project

Data Safety and Monitoring Board (DSMB) meetings (se abrirá en una nueva ventana)

Organization and minuting of DSMB meetings

Final Stewardship Plan (se abrirá en una nueva ventana)

Stewardship plans outline how to achieve the optimal use of an intervention, including, for example, how to avoid irrational use, overuse or abuse of health technologies.” A final plan will be made availabe in M12

Clinical Trial Report (se abrirá en una nueva ventana)

This is the report of the clinical activities and will include the end of follow up report of both mothers and infants.

Stewardship plan (se abrirá en una nueva ventana)

Stewardship plans outline how to achieve the optimal use of an intervention, including, for example, how to avoid irrational use, overuse or abuse of health technologies.” A draft plan will be made available in M6.

Updated plan for the exploitation and dissemination of results including communication activities (se abrirá en una nueva ventana)

We will reassess our previous developed Plan for the exploitation and dissemination of results including communication activities for compliance with Horizon Europe requirements. An updated version will be available at M6

Collection of documents related to the status of the clinical trial (se abrirá en una nueva ventana)

deliverable Provision of EDCTP2 project documents to be shared as background information. These include:-Initial study package of Pyrapreg-Final version of study protocol-Ethical approvals-Data and Safety Monitoring Board reports-Publications

Master Degrees (2) (se abrirá en una nueva ventana)

Two Masters students have completed their training.

Maternal Safety Report (se abrirá en una nueva ventana)

Report on maternal AE, AESI and SAE

Networking Progress Report (se abrirá en una nueva ventana)

List of updates in the dissemination tools.

PhD Degrees (2) (se abrirá en una nueva ventana)

Two PhD students have completed their PhD training

Trail Steering Committee (TSC) meetings (se abrirá en una nueva ventana)

Organization and minuting of TSC meetings

Updated Data Management Plan (se abrirá en una nueva ventana)

The MRC-The Gambia of LSTMH is responsible for the data management of the project. A data management plan (DMP) has been put in place under EDCTP 2. An updated DMP will be made available at M6.

Study final report (se abrirá en una nueva ventana)

This is the overall report of the entire study including all the different work packages.

Final report (se abrirá en una nueva ventana)

Report describing the final outcomes of the project as per EU regulations

Population PK Report (se abrirá en una nueva ventana)

Summary report on the population PK and PKPD modelling of pyronaridine in pregnant and non-pregnant malaria patients, including pregnancy effects and exposure-response analysis

Report on the status of posting results (se abrirá en una nueva ventana)

Report on the posting of summary trial results in the applicable registry/ies (where the study was registered).

Infant Safety Report (se abrirá en una nueva ventana)

Safety outcome after one year.

Global Access Plan (se abrirá en una nueva ventana)

Proportional global access plan describing potential registration and access items

OEI - EPQ - Requirement No. 1 (se abrirá en una nueva ventana)

Ethics Advisor: An external independent ethics advisor needs to be appointed to advise the project participants on ethics issues, in particular the need to address ethical risks related to the involvement of vulnerable populations (pregnant women and children) in the research and to ensure that their interests are adequately protected. The ethics advisor should have expertise in research ethics in general and substantial experience in the assessment of ethics issues in the specific topic area of this project.An ethics report by ethics external advisor should be provided.

Publicaciones

Impact of malaria in pregnancy on infant neurodevelopment and malaria susceptibility during the first year of life in Kinshasa, the Democratic Republic of the Congo (se abrirá en una nueva ventana)

Autores: Japhet Kabalu Tshiongo, Lise Kuseke, Thierry Kalonji, Patrick Mitashi, Aimée Mupuala, Kassoum Kayentao, Trésor Zola Matuvanga, Vivi Maketa Tevuzula, Yann Kafala, Henk D.F.H. Schallig, Hypolite Muhindo Mavoko, Petra F. Mens
Publicado en: International Journal of Infectious Diseases, 2025, ISSN 1201-9712
Editor: Elsevier BV
DOI: 10.1016/J.IJID.2025.107927

Congenital malaria in newborns of mothers living in highly endemic parts of Kinshasa, Democratic Republic of Congo (se abrirá en una nueva ventana)

Autores: Japhet Kabalu Tshiongo, Lise Kuseke, Vivi Maketa Tevuzula, Flory Luzolo, Yann Kafala, Evodie Ngelesi, Moussa Djimde, Patrick Mitashi, Thierry Kalonji-Mukendi, Damien Mbanzulu Pita Nsonizau, Kassoum Kayentao, Petra F. Mens, Ryan van den Bos, Hypolite Muhindo Mavoko, Henk D. F. H. Schallig
Publicado en: Paediatrics and International Child Health, 2025, ISSN 2046-9047
Editor: Informa UK Limited
DOI: 10.1080/20469047.2025.2459964

Importance of Lysosomal Trapping and Plasmodium Parasite Infection on the Pharmacokinetics of Pyronaridine: A Physiologically Based Pharmacokinetic Model-Based Study (se abrirá en una nueva ventana)

Autores: Wan-Yu Chu, Wietse M. Schouten, Hypolite Muhindo Mavoko, Japhet Kabalu Tshiongo, Doudou Malekita Yobi, Freddy-Arnold Kabasele, Gustave Kasereka, Vivi Maketa, Esperança Sevene, Anifa Vala, Jangsik Shi
Publicado en: Clinical Pharmacokinetics, 2025, ISSN 0312-5963
Editor: Springer Science and Business Media LLC
DOI: 10.1007/S40262-025-01581-6

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