Objective
MAIN HYPOTHESIS: Changes in chromatin drive evolution and adaptation in eukaryotes.
MAIN OBJECTIVE: This project aims to understand the impact of epigenetic regulation on the evolution of eukaryotes adapted to extreme environments. To achieve this objective, I will use two approaches involving extremophilic eukaryotes: 1) Identify chromatin signatures to evaluate the potential roles of chromatin in adapting to extreme environments. 2) Use experimental evolution to examine how chromatin affects their capacity for adaptation.
BACKGROUND: My previous research identified genome size reduction as a broad signature of adaptation strategies in extremophilic eukaryotes. In particular, an unanticipated loss of several canonical epigenetic pathways took place during the evolution of extremophilic red algae. I hypothesize that global changes in chromatin features have influenced the adaptation to extreme environments in eukaryotes.
STRATEGIES: I will apply orthogonal strategies to investigate the function of chromatin in environmental adaptability. I will use multi-omics to reveal adaptation signatures based on the comparison of the composition and maps of chromatin features between extremophilic and mesophilic groups. Genetic engineering in model red algae will identify the chromatin machinery that impacts adaptation to extreme environments. Finally, experimental evolution will be used to characterize how the specific chromatin composition of extremophilic red algae impacts adaptation capacity.
IMPACT: This work will establish how chromatin influences the evolution of eukaryotes with direct experimental evidence. It will demonstrate how specific chromatin components impact eukaryotic adaptations and eventually identify some macro-evolutionary trends that participate in the emergence of new eukaryotic lineages.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
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Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinator
1030 Wien
Austria