Objective
Carbon-carbon (C-C) bond formation is one of the most challenging synthetic reactions in chemistry. Current approaches require expensive and toxic transition metals with complex ligands that have limited selectivity. Developing biocatalytic sustainable methods for the controlled formation of C-C bonds with stereospecificity in high yields has the potential to advance organic chemistry and provide access to new molecules. Although several enzymes are capable of catalyzing C-C bonds, few biocatalytic approaches have been used in organic synthesis, with aldolases being the most used enzyme group. PLP-dependent transaminases (TA) are the largest and most versatile group, and used at industrial scale, but have never shown C-C bond formation activity. In this project, I will be developing biocatalytic approaches for C-C bond formation by exploring this new functionality of these versatile enzymes. Thus, I will explore the catalytic versatility of TAs through protein engineering to allow C-C bond formation. Protein immobilization of engineered TAs will support their biocatalytic application in preparative C-C bond formation reactions. This will expand the biocatalytic toolbox available for synthesis, and improve sustainability.
This project will be carried in the Biocatalysis section at TU Delft, where I will receive training in protein engineering, while using my experience in immobilization, and co-supervise students. This project will give me the opportunity to further develop the research and supervision skills to become a future group leader.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences catalysis biocatalysis
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2628 CN DELFT
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.