Project description
Cancer treatment with targeted nanoparticles
Cancer remains a complex global health challenge despite the arsenal of existing treatments, including radiotherapy, chemotherapy, and emerging options like immunotherapy and precision medicine. Nanotechnology has introduced innovative nanoparticle (NP)-based therapies with the potential to revolutionise treatment, but these technologies have yet to make a significant clinical impact. The main obstacle is their inability to effectively target tumours due to issues with selective delivery. With the support of the Marie Skłodowska-Curie Actions programme, the DEXTER project aims to address this gap by developing bioartificial extracellular vesicles (EVs) that maintain targeting properties even after being loaded with therapeutic NPs. By resolving critical issues related to exosome stability and immune system interactions.
Objective
In spite of a growing toolbox of therapies, including classical (radiotherapy, chemotherapy or surgery) and emerging (immunotherapy, precision medicine or hormone therapy) treatments, cancer is a multifaceted global health issue that continues to demand new solutions. The advent of nanotechnology has added nanoparticle (NPs)-based approaches to the available toolbox in cancer therapy. Indeed, we now have NPs with extraordinary properties, including drug loading, antibody functionalization and remote activation capabilities. However, these promising advances have so far failed to materialize in the clinic, largely due to a lack of selective delivery to tumors. DEXTER attempts to change this situation by combining recent multidisciplinary advances in the fields of nanomedicine and extracellular vesicles (EVs). Specifically, DEXTER aims to develop new procedures to create bioartificial EVs that maintain selective targeting properties after loading them with therapeutic NPs. These artificial EVs have the potential to overcome the limitations of using native EVs, whose targeting and immune system-evading properties are compromised after loading with NPs. For this, fundamental problems need to be resolved to realize their potential for application in the clinic. In particular, there is a clear lack of understanding regarding the stability of exosomes during long-term storage as well as their interactions with cells from the immune system in their application in vivo. DEXTER will shed light on the key factors that govern the fate of NPs-loaded exosomes, providing clues to modify them in order to achieve a strong enhancement of their ability for selective delivery of therapeutic loads to tumors. The developing of DEXTER in the host institution will allow me to mature and acquire new research lines, developing new competences in nanotechnology and chemical technology research, and will be crucial to encourage my independency in this stage of my career.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
50009 ZARAGOZA
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.