Objective
Antiretroviral therapy (ART) blocks HIV replication but cannot eliminate viral reservoirs that originate viral rebound if ART is discontinued. However, the host laboratory originally described some individuals, post-treatment controllers (PTC), capable to durably control viremia after ART discontinuation. More recently, the group has found that HLA B*35 alleles (usually associated with rapid progression in the absence of ART) are paradoxicaly overrepresented in PTCs and are accompanied with an MHC immunogenetic fingerprint (termed Bw4TTC2 by the lab), related to KIR-education of NK cells. The proposed work aims to better characterize transcriptional and functional signatures of NK cells in PTC and other people with HIV (PWH), their evolution since primary infection, during ART, and after ART discontinuation, and in regard of immunogenetic factors. These will be done in three different settings: (i) crossectional analysis in groups of people with well-characterized HIV status; (ii) longitudinal samples from the biobank of the primate-VISCONTI study (pVISCONTI); (iii) prospective study of samples from individuals on ART since primary HIV infection and carrying B*35 Bw4TTC2 , who will undergo ART interruption (ATI) in the context of the ANRS RHIVIERA01 clinical trial. Overall, this proposal should unveil the phenotype and functional activities of NK cell subsets more relevant to post-treatment control, the influence of early ART initiation and of immunogenetic factors. This information may provide important insight for the development of new immunotherapies aiming HIV remission.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences basic medicine immunology immunotherapy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75724 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.