Objective
Magnetic resonance imaging (MRI) is an excellent technique for medical diagnosis. Nonetheless, people from rural areas and low-income countries cannot access MRI due to its high associated cost.
In recent years, low-field MRI has emerged as a potential solution to increase access to MRI, but at the cost of reduced signal sensitivity. This is a limiting factor in terms of resolution, traceable quantities of metabolites, and early detection of tumor tissue.
In this context, hyperpolarization (HP) has emerged as the most promising technique to compensate for the sensitivity losses at low magnetic fields. HP can enhance signal intensity by >10,000 times, providing enough signal to image even species at low concentrations, such as metabolites internalized by cancer cells.
Here, the first in vivo metabolic imaging methodology with hyperpolarization at low magnetic fields is proposed. The project involves the development of 1H and HP 13C MRI at low field, the study of enzymatic conversion from HP pyruvate to other metabolites, and in vivo metabolic tumor imaging in mice.
Para-hydrogen-induced polarization (PHIP) will be used to generate the HP contrast agent. PHIP offers several advantages, including low costs, low instrumentation demands, rapid high-throughput, and scalable production of HP agents in the liquid state.
The combination of low-field MRI with PHIP 13C has the potential to provide a method for early cancer detection in a low-cost scanner.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.