Project description
Advancing stroke rehabilitation with brain-heart biomarkers
Stroke, a leading cause of disability, often leaves individuals with impaired sensorimotor abilities. While brain-computer interfaces (BCIs) hold promise in rehabilitation, their effectiveness varies due to the need for individual customisation. The absence of objective markers hampers monitoring task performance and progress in BCI interventions. With the support of the Marie Skłodowska-Curie Actions programme, the NETCORE project aims to develop biomarkers from brain-heart interplay, potentially revolutionising stroke rehabilitation. Its innovative methodology combines network science and signal processing to assess motor imagery. By studying healthy participants and stroke patients, NETCORE will offer fresh insights often overlooked in brain damage research.
Objective
Brain-computer interfaces (BCI) hold promise in the restoration of lost sensorimotor abilities after stroke, a leading cause of disability. Yet, their effectiveness varies because BCI typically need to be customized for each patient. For this, the development of objective markers for monitoring task performance, learning, and progress remains one of the main challenges in BCI. We aim to develop biomarkers to assess the effectiveness and progress of BCI interventions. NETCORE focuses on biomarkers derived from brain-heart interplay. This approach has proven valuable, as changes in brain-heart interplay correlate with disrupted perceptual abilities and even severity/mortality after brain damage. Notably, analyzing brain-heart interplay provides more insightful information compared to studying each organ separately. Our innovative methodology combines network science and biomedical signal processing to estimate interactions between these two systems in the context of motor imagery. We will explore various approaches, such as generative data methods, multi-layer networks, higher-order dependencies, and deducing potential causal interactions from physiologically informed neural models. Then, brain-heart interplay will be studied during BCI training progression in healthy participants, to later contrast with a subset of patients who suffered stroke. Traditionally, brain-damage research mainly focuses on the brain itself, overlooking its multisystem impact. Our ultimate goal is to pave the way for future biomedical breakthroughs in the emerging field of brain-heart interplay. Through these efforts, NETCORE strives to enhance the potential of BCI in aiding brain-injured patients and showing the potential of studying brain-heart interplay in healthcare and neuroscientific research. NETCORE's development will take place at the Paris Brain Institute, which provides an ideal interdisciplinary environment for this research in terms of expertise, equipment, and human resources.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- medical and health sciences basic medicine neurology stroke
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75013 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.