Project description
Catalytic synthesis of key chemical compounds
Biaryl compounds are important building blocks in many medicines, materials and natural products. However, making them efficiently is still a challenge due to issues with reactivity, selectivity and sustainability. Traditional methods often struggle to produce these compounds in a straightforward and eco-friendly way. This makes it difficult to create a wide range of valuable, functional molecules. With the support of the Marie Skłodowska-Curie Actions programme, the Cat4Arene project will develop a sustainable method for creating ortho-iodobiaryls and other halogenated arenes. By improving palladium-catalysed reactions, the project offers an alternative way to easily synthesise these compounds. This will make it easier to produce important molecules for the pharmaceutical and agrochemical industries, opening up possibilities for drug and material development.
Objective
In the last 20 years, palladium-catalyzed C–H activation has emerged as a useful alternative to traditional cross-coupling methods and a powerful tool to access valuable intermediates for the synthesis of complex functional molecules. The biaryl fragment is one of the most frequent units present in bioactive molecules, functional organic materials and natural products. Despite major advances, significant limitations persist with regard to their preparation, in term of reactivity, selectivity and sustainability. Based on the recent achievements in the synthesis of ortho-iodobiaryls following a Catellani strategy, the overall objective of this proposal is the development of a general and sustainable method for the direct synthesis of ortho-iodobiaryls and selectively substituted haloarenes as valuable intermediates for the synthesis of a large number of high value-added compounds. The project aims also to develop protocols for the straightforward synthesis of new biaryl-containing phosphines, as a valuable application of this methodology.
CAT4Arene will allow the selective construction of halogenated biaryls and arenes which can be further easily converted into a broad variety of high value-added compounds. In particular, thanks to the easily manipulation of the C-halogen bond, especially C-I and C-Br bonds, these new methodologies will unlock the direct construction of tricky molecular architectures, including biaryl-containing phosphines and bioactive nitrogen derivatives. Likewise, new classes of organic molecules would be also accessed, unlocking the opportunity to enlarge the range of compounds available for the medicinal chemistry and the agrochemical industry. The development of unconventional haloarenes formation protocols will be an outstanding breakthrough for the organic chemistry community.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- medical and health sciencesbasic medicinemedicinal chemistry
- natural scienceschemical sciencesorganic chemistryhydrocarbons
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Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinator
43121 PARMA
Italy