How vertically transmitted gut microbes and immune genes synergistically direct anti-malarial defence in birds

Informations projet

BornThisWay

N° de convention de subvention: 101152455

DOI 10.3030/101152455

Date de signature de la CE 12 Mai 2024

Date de début 1 Septembre 2025

Date de fin 31 Août 2027

Financé au titre de

• Marie Skłodowska-Curie Actions (MSCA)

Coût total Aucune donnée

Contribution de l’UE € 206 887,68

Coordonné par

LUNDS UNIVERSITET
Sweden

Objectif

Mounting an appropriate and effective immune response is critical to protect an organism from infection. In vertebrates, the adaptive immune system (AIS) plays a central role in immunity, and evidence is accumulating that its development is governed by intricate crosstalk between host immune genes and gut bacteria (GB). This implies that specific synergisms exist between bacterial taxa and AIS, mainly encoded by the highly polymorphic Major Histocompatibility Complex genes (MHCs), to promote optimal immunity. However, the specific associations between GB and MHCs in defence against parasites and their potential effects across generations are poorly resolved in one of the largest vertebrate classes: the birds. BornThisWay will close major gaps in our current understanding of immune consequences of GB-MHC crosstalk in wild birds using two ideal study populations. The action will capitalise on my and my host’s (Prof. Helena Westerdahl) extensive backgrounds in avian gut microbiomes and avian adaptive immunity, respectively. BornThisWay will i) establish how GB and MHC act in concert to defend against avian malaria parasites, ii) determine if synergistically optimal protection is transferred across generations, and iii) test immune consequences of GB-MHC crosstalk disruptions. BornThisWay will add a new dimension to host-pathogen interactions in wild birds, generate novel fundamental insights into the adaptive significance of GB-MHC crosstalk, and provide transformative insights of conceptual and empirical value to transgenerational immunity in vertebrates.

Champ scientifique (EuroSciVoc)

CORDIS classe les projets avec EuroSciVoc, une taxonomie multilingue des domaines scientifiques, grâce à un processus semi-automatique basé sur des techniques TLN.

• sciences médicales et de la santé › sciences de la santé › maladie infectieuse › paludisme
• sciences naturelles › sciences biologiques › microbiologie › bactériologie

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Mots‑clés

• Birds
• Gut microbiomes
• Malaria infections
• MHCs
• Transgenerational immune priming

Programme(s)

• HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme

Thème(s)

• HORIZON-MSCA-2023-PF-01-01 - MSCA Postdoctoral Fellowships 2023

Appel à propositions

HORIZON-MSCA-2023-PF-01

Régime de financement

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

Coordinateur

LUNDS UNIVERSITET

• Contribution nette de l'UE: € 206 887,68
• Adresse: Paradisgatan 5c ; 22100 Lund ; Suède
• Région: Södra Sverige › Sydsverige › Skåne län
• Type d’activité: Higher or Secondary Education Establishments
• Coût total: Aucune donnée