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Origami-DNA/AgNCs Sensor for Detection of miRNAs

Objective

Breast cancer (BC) is a prevalent kind of cancer worldwide and it is one of the primary causes of cancer-related deaths in women. The research has shown that early detection of BC could significantly increase the chances of survival for patients. Recently, there has been a growing interest in microRNAs (miRNAs) as potential biomarkers for the early diagnosis of BC. Therefore, the development of new diagnostic tools for the early detection of BC is necessary. Thus, biosensors based on DNA nanotechnology emerge as a novel, versatile, and easily accessible alternative.
In this context, the synergy between the fluorescence properties of DNA/AgNCs and the structural properties of DNA-origami will allow the creation of a new generation of hybrid nanomaterials (nanohybrids), which could be conceived as biosensors for the detection of miRNAs associated to BC with high sensitivity, sequence specificity, high throughput, low cost, and easy access.
ODASMIR aims to design origami-DNA/AgNCs nanohybrids (ODAs) to develop a biosensor to diagnose BC through the detection of different miRNAs and, it will validate in in vitro models (2D and 3D). ODASMIR presents a multidisciplinary approach, both the objectives and the experimental methodology are on the interface between biology and chemistry. The biosensors obtained and their validation at the clinical level could have a significant impact on the accurate and early diagnosis of BC representing a significant advance in the field of nanomedicine.

Fields of science (EuroSciVoc)

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

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HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

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(opens in new window) HORIZON-MSCA-2023-PF-01

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Coordinator

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 181 152,96
Address
COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N
15782 Santiago De Compostela
Spain

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Region
Noroeste Galicia A Coruña
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

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