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CORDIS - Résultats de la recherche de l’UE
CORDIS

Origami-DNA/AgNCs Sensor for Detection of miRNAs

Objectif

Breast cancer (BC) is a prevalent kind of cancer worldwide and it is one of the primary causes of cancer-related deaths in women. The research has shown that early detection of BC could significantly increase the chances of survival for patients. Recently, there has been a growing interest in microRNAs (miRNAs) as potential biomarkers for the early diagnosis of BC. Therefore, the development of new diagnostic tools for the early detection of BC is necessary. Thus, biosensors based on DNA nanotechnology emerge as a novel, versatile, and easily accessible alternative.
In this context, the synergy between the fluorescence properties of DNA/AgNCs and the structural properties of DNA-origami will allow the creation of a new generation of hybrid nanomaterials (nanohybrids), which could be conceived as biosensors for the detection of miRNAs associated to BC with high sensitivity, sequence specificity, high throughput, low cost, and easy access.
ODASMIR aims to design origami-DNA/AgNCs nanohybrids (ODAs) to develop a biosensor to diagnose BC through the detection of different miRNAs and, it will validate in in vitro models (2D and 3D). ODASMIR presents a multidisciplinary approach, both the objectives and the experimental methodology are on the interface between biology and chemistry. The biosensors obtained and their validation at the clinical level could have a significant impact on the accurate and early diagnosis of BC representing a significant advance in the field of nanomedicine.

Champ scientifique (EuroSciVoc)

Mots‑clés

Programme(s)

Thème(s)

Régime de financement

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Appel à propositions

(s’ouvre dans une nouvelle fenêtre) HORIZON-MSCA-2023-PF-01

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Coordinateur

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Contribution nette de l'UE
€ 181 152,96
Adresse
COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N
15782 Santiago De Compostela
Espagne
Région
Noroeste Galicia A Coruña
Type d’activité
Higher or Secondary Education Establishments
Liens
Coût total
Aucune donnée