Project description
Green chemistry with CO2 fixation
Traditional methods for synthesising chiral carboxylic acids rely on processes like hydrogenation and hydroxycarbonylation, which often lack efficiency and sustainability. A direct, catalytic approach using CO2 offers a greener alternative but remains largely underdeveloped. With the support of the Marie Skłodowska-Curie Actions programme, the CO2PPER project aims to revolutionise this field by leveraging stable alkylboronic esters in copper-catalysed carboxylation reactions. This method promises to overcome barriers in CO2 fixation, enabling the efficient production of enantioenriched chiral carboxylic acids. By using copper catalysts, known for their cost-effectiveness and low energy requirements, CO2PPER introduces an innovative, environmentally friendly strategy that advances CO2 valorisation while supporting sustainable chemical synthesis.
Objective
CO2PPER aims to explore a comprehensive method for the under-investigated catalytic CO2 fixation in asymmetric carboxylation reactions to produce chiral carboxylic acids. Unlike traditional methods that rely on asymmetric hydrogenation of α,β-unsaturated acids and hydroxycarbonylation of alkenes, catalytic CO2 fixation provides a direct and environmentally preferable alternative. Despite recent efforts in creating new chiral ligands to manage reactivity and selectivity, developing a universal catalytic carboxylation using CO2 remains an unsolved problem. CO2PPER proposes a novel approach by employing stable and easily accessible sterodefined alkylboronic esters in metal-catalyzed carboxylations to prepare a broad range of enantioenriched chiral carboxylic acids. The CO2 insertion will be achieved by the use of abundant and inexpensive copper-catalysts, taking advantage of the lowest energy barrier for CO2 insertion into a M-C bond. This project will significantly contribute to the advancement of the CO2-valorization framework and presents an innovative green methodology for chiral carboxylic acid synthesis.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
28049 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.