Project description
Green chemistry with CO2 fixation
Traditional methods for synthesising chiral carboxylic acids rely on processes like hydrogenation and hydroxycarbonylation, which often lack efficiency and sustainability. A direct, catalytic approach using CO2 offers a greener alternative but remains largely underdeveloped. With the support of the Marie Skłodowska-Curie Actions programme, the CO2PPER project aims to revolutionise this field by leveraging stable alkylboronic esters in copper-catalysed carboxylation reactions. This method promises to overcome barriers in CO2 fixation, enabling the efficient production of enantioenriched chiral carboxylic acids. By using copper catalysts, known for their cost-effectiveness and low energy requirements, CO2PPER introduces an innovative, environmentally friendly strategy that advances CO2 valorisation while supporting sustainable chemical synthesis.
Objective
CO2PPER aims to explore a comprehensive method for the under-investigated catalytic CO2 fixation in asymmetric carboxylation reactions to produce chiral carboxylic acids. Unlike traditional methods that rely on asymmetric hydrogenation of α,β-unsaturated acids and hydroxycarbonylation of alkenes, catalytic CO2 fixation provides a direct and environmentally preferable alternative. Despite recent efforts in creating new chiral ligands to manage reactivity and selectivity, developing a universal catalytic carboxylation using CO2 remains an unsolved problem. CO2PPER proposes a novel approach by employing stable and easily accessible sterodefined alkylboronic esters in metal-catalyzed carboxylations to prepare a broad range of enantioenriched chiral carboxylic acids. The CO2 insertion will be achieved by the use of abundant and inexpensive copper-catalysts, taking advantage of the lowest energy barrier for CO2 insertion into a M-C bond. This project will significantly contribute to the advancement of the CO2-valorization framework and presents an innovative green methodology for chiral carboxylic acid synthesis.
Keywords
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinator
28049 Madrid
Spain