Description du projet
Les diverses facettes de la douleur chronique
La douleur musculo-squelettique chronique est souvent associée à des incapacités fonctionnelles débilitantes, qui constituent la principale plainte en clinique. Les mécanismes sous-jacents demeurent malheureusement peu clairs et sous-étudiés. Soutenu par le programme Actions Marie Skłodowska-Curie, le projet PROTECT entend remédier à cet état de fait. L'équipe étudiera l'impact de l'identité athlétique et de la fatigue mentale et physique sur la relation entre la résilience et les handicaps fonctionnels par le biais de questionnaires, de tâches physiques et comportementales et de la modélisation informatique. PROTECT procédera également à des études d'IRM fonctionnelle pour évaluer les changements dans la connectivité du «réseau de mode par défaut», qui ont été associés à la douleur aiguë et chronique, à la résilience et à l'identité athlétique.
Objectif
Chronic musculoskeletal pain is a major health issue, which translates into a severe economic burden. Studies on chronic pain conditions have focused primarily on characterizing pain mechanisms with a focus on alleviating clinical pain intensity. The success of these studies in terms of effective treatment remains extremely limited. Rather than focusing on pain intensity, PROTECT will focus on functional disabilities associated with chronic musculoskeletal pain, which are the main complain of patients. They can be extremely debilitating and often result in social isolation of persons with chronic musculoskeletal pain. To date, their mechanisms remain poorly understood. A better understanding of these mechanisms is essential to improve treatment efficiency.
In work package (WP) 1 of PROTECT, the impact of athletic identity and mental and physical fatigue on the relationship between resilience and functional disabilities will be studied in adults and minors with chronic musculoskeletal pain (RO1). Resilience is associated with functional disabilities, athletic identity and fatigue, a frequent comorbidity of chronic musculoskeletal pain. Characterizing the complex relationship between these factors using computational modeling will define new treatment targets that can be addressed by adapting already available therapeutical interventions. All factors will be assessed using questionnaires, as well as physical and behavioral tasks. In WP2, resting-state fMRI will be used to assess brain networks of functional disabilities in adults with chronic musculoskeletal pain. In particular, the role of the Default Mode Network (DMN) in functional disabilities will be investigated (RO2). Changes in DMN connectivity have been associated with acute and chronic pain, as well as with resilience and athletic identity. Finally, PROTECT will focus on the potentially mediating role of resilience and athletic identity on the relationship between the DMN and functional disabilities (RO3).
Mots‑clés
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régime de financement
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinateur
40225 Dusseldorf
Allemagne