Objective
The prevalence of type 2 diabetes mellitus (T2D), cardiovascular disease (CVD), and dementia is rapidly increasing worldwide and is therefore a major public health concern. Carbohydrate intake (40-80%) represents the main source of energy in most populations and the quality more than the quantity has a large effect on health. Recently, a “carbohydrate quality index” (CQI) emerged as a exposure that captures the combined and potentially synergistic effects of dietary glycemic index and intakes of total fiber, whole grains, and liquid or solid carbohydrates in a comprehensive manner. A high dietary carbohydrate quality assessed by the CQI has been associated with lower risk of T2D, CVD, and intermediate risk factors. However, the precise mechanisms of the associated beneficial effects offered by high CQI scores remain unresolved partially due to the lack of accurate biomarkers reflecting their exposure and the minimal information available on how CQI impacts the gut microbiota. The main objective of BISCUITS is to identify multi-omics signatures of dietary carbohydrate quality assessed by the CQI and evaluate their associations with the risk of chronic diseases in adult populations. We will integrate metabolomics and microbiota datasets using novel machine learning algorithms to identify combined panels of metabolites and microbial species reflecting the exposure to high CQI scores. We will also investigate the potential associations of these signatures with the risk of T2D, CVD, and dementia in two populations. Similar studies to this are not available in the literature and have the potential to discover novel biomarkers of CQI exposure and map biochemical mechanisms explaining the complex relationship between CQI and these diseases. This could open new avenues for the prevention and management of cardiometabolic and neurodegenerative diseases, resulting in easy-to-follow lifestyle recommendations and strategies that general population and patients can easily adopt.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering fibers
- agricultural sciences agriculture, forestry, and fisheries agriculture grains and oilseeds
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
412 96 Goteborg
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.