Objective
Post-traumatic epilepsy (PTE) is one of the most common, devastating complications following traumatic brain injury (TBI), and is particularly prone to drug-refractoriness. Critically, current anti-seizure medication remains ineffective in over 30% of patients, with no impact on disease progression and frequent adverse side effects. Increasing evidence suggests inflammation as one of the main contributors to the development of PTE. ATP, released during pathological processes in the brain, functions as an important extracellular signalling molecule driving inflammatory processes via the activation of the ATP-gated ionotropic P2X7 receptor (P2X7R). Increasing evidence suggests that targeting of the P2X7R provides potent anticonvulsive effects and, possibly, disease-modification during epilepsy. Whether P2X7R antagonism prevents the development of PTE has not been investigated to date. My planned research will 1) investigate the disease-modifying potential of targeting the ATP-gated P2X7R on TBI-induced epilepsy and associated comorbidities, thereby sparing patients from life-long drug dependency, and 2) evaluate the potential of P2X7R-based PET imaging as novel patient stratification tools to identify patients at risk of developing PTE for an earlier and more effective treatment start. EpiPrevent brings together a team of experts in purinergic signalling, industrial partners developing novel P2X7R antagonists and clinicians specialised in epilepsy. This highly interdisciplinary and intersectoral approach will add a significant contribution to the understanding of purinergic signalling during TBI, providing novel diagnostic and therapeutic approaches. The skills acquired during the research project, the excellent training record of the supervisor and host institution and the outstanding resources for learning and development available at RCSI will give me the tools necessary to establish myself as independent scientist.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology epilepsy
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
2 DUBLIN
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.