Project description
Advanced mass spectroscopy approach to exploring metal complexes
Electrospray ionisation mass spectrometry (ESI-MS) is a powerful tool for studying various molecules and complexes. Recently, it has been enhanced by being integrated with ion mobility spectrometry (IMS), which helps separate ions with identical mass-to-charge ratio but different sizes and shapes. Funded by the Marie Sklodowska-Curie Actions programme, the ME-COMPLEX project harnesses this integrated technology to explore siderophore-metal complexes (SMCs) in seawater and the rhizosphere. By varying ESI parameters and solution conditions, the research aims to study SMC stability, hydrolysis and fragmentation patterns. Research will also be geared towards theoretical calculations for collision cross-sections and thermodynamic properties to derive additional information on SMC structures. This multidisciplinary research spans analytical chemistry, environmental science and quantum mechanics.
Objective
The electrospray ionization with mass spectrometry detection (ESI-MS) has been widely used to study biomolecules, low molecular weight compounds, and noncovalent complexes. Ion mobility spectrometry (IMS), capable of separating ions with the same m/z but varying sizes and shapes in the gaseous phase, has been recently hyphenated with the ESI-MS to conduct fundamental and applied research. The overall objective of this proposal is to generate new knowledge on the biological function and chemical characteristics of siderophore-metal complexes (SMCs) under real conditions such as seawater and rhizosphere by harnessing in-source activation (ISA) and cutting-edge ESI-IM-MS technology. To this end, the experimental investigations will involve varying ESI parameters, such as ESI and ISA voltages and drying gas temperature, and solution conditions, e.g. pH, solvent type, ionic strength, and matrix, to investigate stability and competitivity, hydrolysis, hydrogen-deuterium exchange behavior, and fragmentation patterns of SMCs plus finding the binding site locations of siderophores to metal ions in SMCs. The proposed project will also include experimental and theoretical calculations of collision cross-section (CCS) values and thermodynamic studies via quantum-mechanical methods, i.e. density functional theory to rationalize the experimental observations. The obtained CCS values will allow us to derive additional structural and spatial information on the investigated SMCs. The proposed project is multidisciplinary in nature as it integrates analytical chemistry, soil/plant research, environmental science, physical chemistry, and quantum mechanics. Two-way knowledge transfer in this project ensures the transfer of the candidate's expertise in the areas of sample preparation, flow systems, and 3D-printing technology to the host institution and training of the candidate in advanced analytical chemistry techniques to enhance his employability and career development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1180 Wien
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.