Objective
Fibroblast activation protein (FAP) is a serine protease that is highly expressed on cancer-associated-fibroblasts (CAFs), in nearly all tumor types. Its limited presence in healthy tissues makes it an attractive diagnostic and therapeutic biomarker for cancer. UAMC1110, a potent and specific FAP inhibitor discovered by the host, opened the way for the development of the so-called FAPIs. These are tumor-targeting molecules composed of a UAMC1110 moiety and a radionuclide. The latter can either be a diagnostic radionuclide for PET imaging, or a more cytotoxic radionuclide for cancer therapy. Radiodiagnostic FAPIs are now entering clinical practice, but their therapeutic counterparts face challenges, related to the relatively short tumor residence time of currently available molecules. The latter leads to significant leaking of toxic radioactivity from the tumor. To overcome this issue, we will develop ketoFAPIs that form long-lived covalent bonds with FAP. This should already ensure significantly longer tumor residence. The ketoFAPIs will also be bound to the surface of gold nanoparticles (AuNPs). The resulting constructs could have further increased tumor residence through the multivalency effect. This interdisciplinary proposal covers 1) the chemical preparation of novel ketoFAPIs and derived AuNPs, 2) their in vitro characterization and 3) in vivo investigation in a mouse model of colorectal cancer. Overall, the project can lead to safer and more efficient FAPIs for radiotherapy applications. The status of FAP as a pan-cancer biomarker entails that these FAPIs could be applied in nearly all cancer types.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- natural sciencesbiological sciencesbiochemistrybiomoleculesproteins
- medical and health sciencesclinical medicineoncology
- engineering and technologynanotechnologynano-materials
- natural scienceschemical sciencesnuclear chemistryradiation chemistry
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Keywords
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsCoordinator
2000 Antwerpen
Belgium